ID U3I6A9_ANAPP Unreviewed; 995 AA.
AC U3I6A9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Integrin subunit alpha 2b {ECO:0000313|Ensembl:ENSAPLP00000002780.2};
GN Name=ITGA2B {ECO:0000313|Ensembl:ENSAPLP00000002780.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000002780.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000002780.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000002780.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; U3I6A9; -.
DR STRING; 8840.ENSAPLP00000002780; -.
DR Ensembl; ENSAPLT00000003373.2; ENSAPLP00000002780.2; ENSAPLG00000003235.2.
DR GeneTree; ENSGT00940000160724; -.
DR HOGENOM; CLU_004111_4_0_1; -.
DR OMA; DCGNATC; -.
DR Proteomes; UP000016666; Chromosome 28.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 24..995
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5019611401"
FT TRANSMEM 946..968
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 30..91
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 245..310
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 311..370
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 373..434
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 420..569
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 574..676
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 776..935
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 995 AA; 106542 MW; D2D98F183B6AC340 CRC64;
MGAVCCAPAP LVALLLLWGL CWASGPELLH PRPAVYEGPP GSYFGFSLDF YVTKNRTRVA
VGAPRANTSQ PGVVEPGAVF LCSWPGNSSC DPVPFDTMET SSSMKLHVYK SRQWLGASVT
SWHGTLVACA PLQHWNAIQD NLEAFRTPVG ACFMGAEGLH RFIWYSPCRS TQMAPVYRKN
EYSECGQGAA GAPPAGTLAL GAPGGYYFKG LHLPPVTPLH LPPHSTPCSP LCPAGRGATC
TSQPRYHPLP PLSQVASYFG HTVAVADING DGRDDILVGA PLYMERRPEG KLSEVGRLYL
YLQRGQWSFA KPPQTLTGTH PYGRFASAIA SLGDLDKDGY GDVAVGAPFG GDSSSGQVLI
FRGQREGLEP VPTQRLDSPF PGPAAFGFAL RGATDLDGNG YMDLLVGAFG ADKVAVYWGQ
PVVVARAQLS VPSGLNPETM ECVLPDSDTR ISCFPVVLCV SVTGQNISQS IRKYLDAELQ
LDRLKPKLSR RVLLLQGHQT SWHQTLVLAI GTSPLCHNLT AYLRDKADFK DKLSPIVTSL
SLALASSSDA QGLGLVLYGD TLVQAQTHIV LEDCGEDNVC VPDLRLTAHT PGTHLLIGAE
NVVSLRAQAT NAGEGAFEAE LRVQLPEDTY YQKALSNIQG QEKLSCIPRK ENGSRVVLCE
LGNPMKAGAQ EVTVPMLSVS PDVRGGEGGG GSVTLPALTP PCPCSKNSPT SAVVTVVVPV
EAQAAMELRG WHGAEGSRRL EDHGIRVEHV YQVGYSTQGC HLRPRVTHCH LPVLPQLHNK
GPATVTNVTL RLDVPTEIDG RILFYLLELG TEGGISCTQP PGLNPKQVGH EGGDSTHPVG
AGGGLRVSPS PSSWKCPNPQ DCGNATCVEV TCWVPSLAKD QRVLVSVRAL LWMDTLQQHL
LKQFLVQSRG FFNTSAMPYR VQPRVLPSGE AEVQLSGPDG KRDVPVWWVV LGILAGILLL
TLLILLMWKV RGGDMTRRCR APLGTPGEGR GPVTP
//
