ID U3I6F0_ANAPP Unreviewed; 1268 AA.
AC U3I6F0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Spalt like transcription factor 1 {ECO:0000313|Ensembl:ENSAPLP00000002821.2};
GN Name=SALL1 {ECO:0000313|Ensembl:ENSAPLP00000002821.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000002821.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000002821.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000002821.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the sal C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00038474}.
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DR STRING; 8840.ENSAPLP00000020776; -.
DR Ensembl; ENSAPLT00000003414.2; ENSAPLP00000002821.2; ENSAPLG00000003356.2.
DR Ensembl; ENSAPLT00000040564.1; ENSAPLP00000020776.1; ENSAPLG00000003356.2.
DR GeneTree; ENSGT00940000155938; -.
DR HOGENOM; CLU_005740_0_0_1; -.
DR OMA; QELHKSP; -.
DR Proteomes; UP000016666; Chromosome 12.
DR GO; GO:0010369; C:chromocenter; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl.
DR GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR GO; GO:0008406; P:gonad development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Ensembl.
DR GO; GO:0061034; P:olfactory bulb mitral cell layer development; IEA:Ensembl.
DR GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd20908; SUF4-like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23233; SAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR23233:SF51; SAL-LIKE PROTEIN 1; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR Pfam; PF12874; zf-met; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 395..422
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 423..450
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 650..677
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 678..705
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 710..737
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 945..972
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 973..1000
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1078..1105
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1106..1133
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 738..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..800
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1268 AA; 135276 MW; 9F369E6B63AAB3F9 CRC64;
MSRRKQAKPQ HFQSDPDLAL LSQRNGDTEK GQANRTTKNK DAHVCGSSPS DNPDEQMNDT
VNNTDQVDCS DLSEHNKLDK EESMDVEASS INNSSSSSKS VNNSITSSNS STMGTSAVTT
SLPHIGDLTT LGNFSVINSN VIIENLQSTK VAVAQFSQEA RCNGASNNKL AVPALMEQLL
ALQQQQIHQL QLIEQIRHQI LLLASQNTDM PTSSSPSQGT LRTSANPLST LSSHLSQQLA
AAAGLAQSLA SQSASISGVK QLPPIQLPQS NPGNTIIPSS SGSSPNINIL AAAVTTPSSE
KVASSIGGSQ LSNPPVSASS SPAFAISSLL SPASNPLLPQ PTPNNSVFSS PLSNIGTPAE
DLNSLTALAQ QRKSKPPNVT AFEAKSNSDE AFFKHKCRFC AKVFGSDSAL QIHLRSHTGE
RPFKCNICGN RFSTKGNLKV HFQRHKEKYP HIQMNPYPVP EHLDNIPTST GIPYGMSIPP
EKPVTSWLDS KPVLSTLTTS VGLPLPPTIP SLTPFIKTEE PQPIPISHPS ASPPCSVKSD
SGTADPTSKI SNGLSDEVEA GALPTSNGKM EENPQNTSSI ANVSSSVSSP AADSGSGSIA
TFTNPLMPLM SEQFKAKFPF GGLLDSTPAS ETSKLQQLVE NIDKKATDPN ECIICHRVLS
CQSALKMHYR THTGERPFKC KICGRAFTTK GNLKTHYSVH RAMPPLRVQH SCPICQKKFT
NAVVLQQHIR MHMGGQIPNT PVTENYPESM ESDTGSFDDK NFDDIDNFSD ENMEDCPDSS
VPDTPKSADA SQDSLSSSPL PLEMSSIAAL ENQMKMINAG LAEQLQASLK SVENGSVEGD
VLTNDSSSVG GDMESQSAGS PAVSESTSSM QALSPSNSTN DYHKSPSIEE KPVRALPSEF
ANGLSPTPAN SGALDLTSSN TDKMIKEESL SMLFPFRDRG KFKNTACDIC GKTFACQSAL
DIHYRSHTKE RPFICTVCNR GFSTKGNLKQ HMLTHQMRDL PSQLFEPSSS IGPNQNSSVM
PANSLSSLIK TEVNGFVHGS PQDSKETPSG LAAAGPLSSS ATSPVLLPAL PRRTPKQHYC
NTCGKTFSSS SALQIHERTH TGEKPFACTI CGRAFTTKGN LKVHMGTHMW NSTPARRGRR
LSVDGPMTFL GGNPVKFPEM FQKDLAARSG NGDPSSFWNQ YAAALSNGLA MKTNEISVIQ
NGGIPPPPGG LGNGGSSPIS GLTGSLEKLP NSEPNAPLAG LEKMASNENG TNFRFTRFVE
DNKEIVTN
//
