ID   U3I790_ANAPP            Unreviewed;       250 AA.
AC   U3I790;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 2.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Transmembrane protein 192 {ECO:0000256|ARBA:ARBA00014635};
GN   Name=TMEM192 {ECO:0000313|Ensembl:ENSAPLP00000003111.2};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000003111.2, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000003111.2, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000003111.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000256|ARBA:ARBA00004603}.
CC       Lysosome membrane {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMEM192 family.
CC       {ECO:0000256|ARBA:ARBA00006314}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; U3I790; -.
DR   STRING; 8840.ENSAPLP00000003111; -.
DR   Ensembl; ENSAPLT00000003706.2; ENSAPLP00000003111.2; ENSAPLG00000003617.2.
DR   GeneTree; ENSGT00390000013749; -.
DR   HOGENOM; CLU_086771_0_0_1; -.
DR   OMA; HGCYIDK; -.
DR   Proteomes; UP000016666; Chromosome 4.
DR   GO; GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   InterPro; IPR029399; TMEM192.
DR   PANTHER; PTHR31592; TRANSMEMBRANE PROTEIN 192; 1.
DR   PANTHER; PTHR31592:SF1; TRANSMEMBRANE PROTEIN 192; 1.
DR   Pfam; PF14802; TMEM192; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   250 AA;  28896 MW;  E1F997363C70D686 CRC64;
     MNMKLLYEIT PLKWCCFLLK RSILMDGENK LMGFFFLPLC FCVAFVVLAF LAAMFCSYPN
     PNQDKCPGNY THPLKVQTVI IIAKVILWIL HVFFERYIHH HHSKVRSRGY FSIYRSTRNL
     KRLPLVIHST GNAALLLILS TQHSFPDHSK VYLYLILGVL GVELISSLTC LVIYTVKISN
     FNRAKPRPDI IEEEKMYAYP SHITSEVGFR ENSSLEEIVE KQGDVIEYLQ RHNALLSKRL
     LALTSQQIKS
//