ID U3I8H1_ANAPP Unreviewed; 304 AA.
AC U3I8H1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Sorting nexin 1 {ECO:0000313|Ensembl:ENSAPLP00000003542.2};
GN Name=SNX1 {ECO:0000313|Ensembl:ENSAPLP00000003542.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000003542.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000003542.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000003542.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR AlphaFoldDB; U3I8H1; -.
DR STRING; 8840.ENSAPLP00000003542; -.
DR Ensembl; ENSAPLT00000004143.2; ENSAPLP00000003542.2; ENSAPLG00000003989.2.
DR GeneTree; ENSGT00940000155889; -.
DR HOGENOM; CLU_022783_2_0_1; -.
DR OMA; EKMAAVW; -.
DR Proteomes; UP000016666; Chromosome 11.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0030905; C:retromer, tubulation complex; IEA:Ensembl.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0005158; F:insulin receptor binding; IEA:Ensembl.
DR GO; GO:1990460; F:leptin receptor binding; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:1990459; F:transferrin receptor binding; IEA:Ensembl.
DR GO; GO:0034498; P:early endosome to Golgi transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR GO; GO:0072673; P:lamellipodium morphogenesis; IEA:Ensembl.
DR GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR10555; SORTING NEXIN; 1.
DR PANTHER; PTHR10555:SF129; SORTING NEXIN-1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..54
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 304 AA; 35595 MW; F3373E2D3AACB002 CRC64;
MTKVKVGKED SSSAEFLEKR RAALERYLRR VVSHPTMLQD PDVREFLEKE ELPRAVGTQA
LSGAGILKMF NKATDAVSKM TIKMNESDIW FEEKLQEVEC EEQRLRKLHA VVETLVNHRK
ELALNTAQFA KSLAMLGSSE DNTALSRALS QLAEVEEKIE QLHQEQANND FFLLAELLGD
YIRLLSVVRG AFDQRMKTWQ RWQDAQTMLQ KKREMEARLL WANKPDKLQQ AKDEISEWES
RVTQYERDFE RISAVIRKEV IRFEKEKSKD FRKHVTKYLE TLLNSQQQLV KYWEAFLPEA
KAIS
//
