ID U3I8V1_ANAPP Unreviewed; 662 AA.
AC U3I8V1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Potassium voltage-gated channel subfamily A member 4 {ECO:0000256|ARBA:ARBA00020938};
DE AltName: Full=Voltage-gated potassium channel subunit Kv1.4 {ECO:0000256|ARBA:ARBA00033201};
GN Name=KCNA4 {ECO:0000313|Ensembl:ENSAPLP00000003672.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000003672.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000003672.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000003672.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, axon {ECO:0000256|ARBA:ARBA00004489}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. A (Shaker) (TC
CC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008202}.
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DR AlphaFoldDB; U3I8V1; -.
DR STRING; 8840.ENSAPLP00000003672; -.
DR Ensembl; ENSAPLT00000004276.2; ENSAPLP00000003672.2; ENSAPLG00000004176.2.
DR GeneTree; ENSGT00940000162248; -.
DR HOGENOM; CLU_011722_4_0_1; -.
DR OMA; GDECSYT; -.
DR Proteomes; UP000016666; Chromosome 5.
DR GO; GO:0043194; C:axon initial segment; IEA:Ensembl.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:UniProt.
DR GO; GO:0030955; F:potassium ion binding; IEA:InterPro.
DR GO; GO:0099508; F:voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; IEA:Ensembl.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.600; Potassium channel, voltage dependent, Kv1.4, tandem inactivation domain; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003972; K_chnl_volt-dep_Kv1.
DR InterPro; IPR020467; K_chnl_volt-dep_Kv1.4.
DR InterPro; IPR012897; K_chnl_volt-dep_Kv1.4_TID.
DR InterPro; IPR037065; K_chnl_volt-dep_Kv1.4_TID_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF284; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 4; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF07941; K_channel_TID; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01511; KV14CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01496; SHAKERCHANEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 324..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 192..292
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 58..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 74047 MW; F34DCB91BA1D7531 CRC64;
MEVAMVSADS SGCNSHMPYG YAVQARARER ERLAQSRAAA AAAVAAATAA VEAGATGGGG
PYHHYHQEQS RGASSSHGGN ASRSSLPNRQ SGKRWKKGKK RSHHLGSREC GASFPCSELL
PLSGSEERIL KDLSEEEEED EDEDEDDEEE GKLYYGADYG EDEFSYSDQP PDDGGGPGGY
SSVRYSEYEC CERVVINVSG LRFETQLKTL AQFPETLLGD PAKRGRYFDP LRNEYFFDRN
RPSFDAILYY YQSGGRLKRP VNVPFDIFSE EVKFYQLGEE AMLKFREDEG FVKEEEDKAL
PENEFKRQVW LLFEYPESSS PARGIAIVSV LVILISIVIF CLETLPEFRD DKEFVMSLSL
GKGLSNESLH LDAGEHTIFN DPFFIVETVC IIWFSFEFTV RCFACPSKAH FFKNIMNIID
IVSILPYFIT LGTDLAQEQG SNGQQAMSFA ILRIIRLVRV FRIFKLSRHS KGLQILGHTL
RASMRELGLL IFFLFIGVIL FSSAVYFAEA DEPATHFQSI PDAFWWAVVT MTTVGYGDMK
PITVGGKIVG SLCAIAGVLT IALPVPVIVS NFNYFYHRET ENEEQTQLMQ NAVSCPYLPT
NLLKKFRSAS SSSTEDKSEY LEMEEGVKES LCVKEKKSQD TGNSSESEKK NCVNSNSVET
DV
//
