ID   U3I8X8_ANAPP            Unreviewed;       239 AA.
AC   U3I8X8;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 2.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=MICOS complex subunit MIC25 {ECO:0008006|Google:ProtNLM};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000003699.2, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000003699.2, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000003699.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane.
CC       {ECO:0000256|ARBA:ARBA00002689}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC       anchor {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion inner membrane
CC       {ECO:0000256|ARBA:ARBA00034476}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00034476}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family. Metazoan
CC       Mic25 subfamily. {ECO:0000256|ARBA:ARBA00034480}.
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DR   AlphaFoldDB; U3I8X8; -.
DR   STRING; 8840.ENSAPLP00000003699; -.
DR   Ensembl; ENSAPLT00000004304.2; ENSAPLP00000003699.2; ENSAPLG00000004192.2.
DR   GeneTree; ENSGT00390000000903; -.
DR   HOGENOM; CLU_049040_3_0_1; -.
DR   OMA; QHTAYLC; -.
DR   Proteomes; UP000016666; Chromosome 13.
DR   GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR   InterPro; IPR007964; MIC19/MIC25.
DR   InterPro; IPR042860; MIC25.
DR   PANTHER; PTHR47609; MICOS COMPLEX SUBUNIT MIC25; 1.
DR   PANTHER; PTHR47609:SF1; MICOS COMPLEX SUBUNIT MIC25; 1.
DR   Pfam; PF05300; MIC19_MIC25; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   239 AA;  27066 MW;  4E92CBF2E5E8D3E9 CRC64;
     MGGSGSRAGG RSVSFGRDER DRVRVLQGVR LSEDVVNRMK ETPQSKRDSQ RSSNGTAPFS
     PAAEGKPKPP TGIQPPTASN SGQKASVAEQ ELYRRYEQEQ ALVQEELLRL AKREREAAGE
     ALSTALQRER NSTNEERQRA AQLPADLDAW AMELQGREAE LKRQEAFYKE QLARIERKNA
     EIYKLTSEQY QEAATKAEEW IKCVIRCQFL QLCKGRGTTL DYVLYLLLQT VTNLYLQQL
//