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Database: UniProt
Entry: U3I9D1_ANAPP
LinkDB: U3I9D1_ANAPP
Original site: U3I9D1_ANAPP 
ID   U3I9D1_ANAPP            Unreviewed;       700 AA.
AC   U3I9D1;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 2.
DT   24-JAN-2024, entry version 57.
DE   SubName: Full=TLE family member 4, transcriptional corepressor {ECO:0000313|Ensembl:ENSAPLP00000003852.2};
GN   Name=TLE4 {ECO:0000313|Ensembl:ENSAPLP00000003852.2};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000003852.2, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000003852.2, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000003852.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC       {ECO:0000256|ARBA:ARBA00005969}.
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DR   AlphaFoldDB; U3I9D1; -.
DR   STRING; 8840.ENSAPLP00000003852; -.
DR   Ensembl; ENSAPLT00000004459.2; ENSAPLP00000003852.2; ENSAPLG00000004314.2.
DR   GeneTree; ENSGT01030000234519; -.
DR   HOGENOM; CLU_007612_3_0_1; -.
DR   OMA; LQRWFCH; -.
DR   Proteomes; UP000016666; Chromosome Z.
DR   GO; GO:1990907; C:beta-catenin-TCF complex; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR005617; Groucho/TLE_N.
DR   InterPro; IPR009146; Groucho_enhance.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR   PANTHER; PTHR10814:SF31; TRANSDUCIN-LIKE ENHANCER PROTEIN 4; 1.
DR   Pfam; PF03920; TLE_N; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR01850; GROUCHOFAMLY.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   DOMAIN          24..131
FT                   /note="Groucho/TLE N-terminal Q-rich"
FT                   /evidence="ECO:0000259|Pfam:PF03920"
FT   REPEAT          500..541
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          542..583
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          624..655
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          32..59
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        144..183
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        184..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   700 AA;  76038 MW;  2378F5D17D3A085C CRC64;
     MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK
     TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV
     TMAELNAIIG SSSVSPSASF RTAEKHRNST DYSSESKKQK TEEKEIAARY DSDGEKSDDN
     LVVDVSNEDP SSPRGSPAHS PRENGLDKTR LLKKDAPISP ASIASSSSTP SSKSKELSLN
     EKSTTPVSKS NTPTPRTDAP TPGSNSTPGL RPVPGKPPGV DPLASGLRTP MAVPCPYPTP
     FGIVPHAGMN GELTSPGAAY AGLHNISPQM SAAAAAAAAA AAYGRSPVVG FDPHHHMRVP
     GIPPNLTGIP GGKPAYSFHV SADGQMQPVP FPPDALIGPG IPRHARQINT LNHGEVVCAV
     TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCRLLP DGRTLIVGGE
     ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV WDLHNQTLVR
     QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI FSLGYCPTGE
     WLAVGMENSN VEVLHVTKPD KYQLHLHESC VLSLKFAHCG KWFVSTGKDN LLNAWRTPYG
     ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY
//
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