ID   U3I9W4_ANAPP            Unreviewed;       313 AA.
AC   U3I9W4;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 2.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 {ECO:0000256|ARBA:ARBA00015852};
DE   AltName: Full=Multisynthase complex auxiliary component p38 {ECO:0000256|ARBA:ARBA00032155};
DE   AltName: Full=Protein JTV-1 {ECO:0000256|ARBA:ARBA00031241};
GN   Name=AIMP2 {ECO:0000313|Ensembl:ENSAPLP00000004035.2};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000004035.2, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000004035.2, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000004035.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; U3I9W4; -.
DR   STRING; 8840.ENSAPLP00000004035; -.
DR   Ensembl; ENSAPLT00000004642.2; ENSAPLP00000004035.2; ENSAPLG00000004525.2.
DR   GeneTree; ENSGT00390000015826; -.
DR   HOGENOM; CLU_076114_0_0_1; -.
DR   OMA; LCQHYRV; -.
DR   Proteomes; UP000016666; Chromosome 15.
DR   GO; GO:0017101; C:aminoacyl-tRNA synthetase multienzyme complex; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:Ensembl.
DR   GO; GO:0060510; P:type II pneumocyte differentiation; IEA:Ensembl.
DR   CDD; cd03200; GST_C_AIMP2; 1.
DR   Gene3D; 1.20.1050.130; -; 1.
DR   InterPro; IPR042360; AIMP2.
DR   InterPro; IPR031889; AIMP2_LysRS-bd.
DR   InterPro; IPR041503; AIMP2_thioredoxin.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004046; GST_C.
DR   PANTHER; PTHR13438; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN; 1.
DR   PANTHER; PTHR13438:SF2; AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2; 1.
DR   Pfam; PF16780; AIMP2_LysRS_bd; 1.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF18569; Thioredoxin_16; 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          1..34
FT                   /note="AIMP2 lysyl-tRNA synthetase binding"
FT                   /evidence="ECO:0000259|Pfam:PF16780"
FT   DOMAIN          112..202
FT                   /note="AIMP2 thioredoxin-like"
FT                   /evidence="ECO:0000259|Pfam:PF18569"
FT   DOMAIN          242..301
FT                   /note="Glutathione S-transferase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00043"
SQ   SEQUENCE   313 AA;  34538 MW;  E849D26AF5FF336E CRC64;
     MPMYKVKPLH GAPGALRAEQ LPSCMYRLPC LHRAAPPAQE EVDPSLQALE SRQEEILKRL
     YELKSAVDGL SKMIQTPDAD FDVTNVIQTD ECSTLTTNGA DLDLMLGKDY GALKDIVINA
     NPSLPPLSLL VLHSLLCEHY KILSAVHTHS SVKSVPESLL KCFGEPTKKQ PRHEYQLGFT
     LIWKDVPKPQ MKFSIQTMCP IEGEGNIARF LFSLFGQKYN AVTSTLIDSW VDTAIFQLKE
     GSSKERGAVL RSMNAALGKT PWLVGNELTV ADIVAWCALQ QTGSTNAAPA NVQKWMKSCE
     NLAPFSSVIK LLK
//