ID U3IC48_ANAPP Unreviewed; 4803 AA.
AC U3IC48;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSAPLP00000004820.2};
GN Name=RYR3 {ECO:0000313|Ensembl:ENSAPLP00000004820.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000004820.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000004820.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000004820.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8840.ENSAPLP00000004820; -.
DR Ensembl; ENSAPLT00000005441.2; ENSAPLP00000004820.2; ENSAPLG00000005134.2.
DR GeneTree; ENSGT00940000155507; -.
DR HOGENOM; CLU_000040_2_0_1; -.
DR OMA; LYNLPHR; -.
DR Proteomes; UP000016666; Chromosome 5.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF9; RYANODINE RECEPTOR 3; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4118..4142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4345..4365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4409..4431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4604..4625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4684..4707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..120
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 127..172
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 180..234
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 240..297
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 550..761
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 977..1173
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1219..1424
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3862..3890
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 3291..3310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3485..3504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3522..3547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4273..4311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3296..3310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3525..3539
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4273..4304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4803 AA; 545761 MW; 9C7F8FA34ECA5F9B CRC64;
KFCLAAEGLG NRLCFLEPTS EAKYVPPDLC ICNFVLEQSL SVRALQEMLA NTGDNAGEGA
AQGGHRTLLY GHAILLRHSF SEMYLTCLTS SRSQTDKLAF DVGLRENAAG EACWWTIHPA
SKQRSEGEKV RIGDDLILVS VSSERYLHLS MSNGSIQVDA SFMQTLWNVH PTCSGSSITE
GYLLGGHVVR FFHGHDECLT IPSTDQNDSQ QKKVLYETGG AGVRARSLWR VEPLRISWSG
SNIKWGQPFR LRHITTGMYL ALNDDEGLVM LDREKSDTTS SAFCFRASKE LKEKQDSTLK
RDIDGMGVPE IKYGDSVCFV QHVASALWLT YKAQDAKSAR LGPLKRKVIL HQEGHMDDGL
TLQRCQHEES QAARIIRNTT SLFSQFISGN NRTLSPIALP VEEMAQTLQD LITYFQPPEE
DLEHEDKQSK LRSLKNRQNL FKEEGMLALV LNCIDRLNDY NSAAHFAEIA REENGTTWKE
ILNLLYKLLA ALIRGNRNNC TQFSSNLDWL ISKLDRLESS SGILEVLHCI LIESPEALNI
IAEEHIKSII SLLDKHGRNY KVLDVLCSLC VCNGVAVRAN QNLICDNLLP RRDLLLQTRL
INDVTSIRPN IFLGVAEGSA QYKKWYFELI IDQVDPFLTA EPTHLRVGWA STSGYAPYPG
GGEGWGGNGV GDDLYSYGFD GLHLWSGRVP RAVASVNQHL LSSDDVVSCC LDLGVPSISF
RINGQPVQGM FENFCTEGFF FPVVSLSAGV KARFLLGGRH GEFKFLPPAG YAPCYEALLP
KEKMKLEPVK EYKRDSDGVR DLLGTTQFLS QASFIPCPID TSQIALPFHL EKIRDKLAEN
IHELWGMNKI ELGWTYGKIR DDNKRHHPCL VEFSKLPETE KNYNLQMSTE TLKTLLALGC
HIVHANPAAE EDLKKVKLPK NYMMSNGYKP APLDLSEVKL LPSQEFLVDK LAENAHNVWA
KDRIKQGWTY GIQQDLKNKR NPRLVPYALL DERTKKSNRD SLREAVRTFA GYGYSVEPPD
QEIADQTTEK VSIDKIRFFR VEQSYAVKSG KWYFEFEAVT GGDMRVGWAR PGCRPDIELG
ADDQAFVFEG SKGQRWHQGS GFFGRSWQPG DVVGCMINLD DKSIIFTLNG ELLITSKGSE
LAFADFGIES GFVPICALGL SQIGRMNLGM DASTFKYYTM CGLQEGFEPF AVNMNRDVAM
WFSKRLPTFV NVPKNHPHIE IWRIDGTIES PPRLKVTHKT FGTQNSNSDM IYCRLSMPIE
FRSSFNFGMG VENIFITNLF FSSFQYFYSL RIFAGQDPSC VWVGWVTPDY HFYSENFDLN
KNCTVTVTLG DERGRVHESV KRSNCYMVWG GDITSNSQRS GRSNVDLEIG CFVDLATGML
SFTANGKELG TCYQVEPNTK LFPATFVQPT STNLVQFELG KLKNTMPLSA AIFKSEERNP
IPQCPPRLDV QTITPVLWSR MPNSFLKVET ERVSERHGWV VQCLEPLQMM ALHIPEENRC
VDILELCEQE DLMKFHYHTL KLYSSVCALG NTRVAYALCS HVDVSQLFYT IDNQYLPGLL
RSGFYDLLIS IHLEHAKQAK LMMNNEFIIP VTEETRTIRL YPDETKKHGL PGVGLSTCLK
PSFHFSTPCF IVTSEEHQTS SPEIPLDTLK SKAISMLTEA VQCSGTHIRD PVGGHITFQF
VPVLKLIATL LIMGVFDDDD VKQVLILIDP NVFGDHKEET EEGTEKEEVT QVEEKAVEAG
EKAIKETKAP TTGLLQTRLP ESVKLQMCHL LNYFCDCELQ HRVEAIVSFA DRYVSKLQYN
QKYRYNELMQ ALNMSAALTA KKTKEFRSPP QEQINMLLNF QLGEDCPCPE EIRDELYDFH
DDLLIHCGIP LEEEEEEEED STLTGKLRSL IYKIKGPPKA EKVEPREEEE KSPTTLKELI
SQTMVRWSQE DQIQDPELVR IMYTLLRRQY DSIGELLQAL RKAYTISAVS VKDTINLLAA
LGQIRSLLSV RMGKEEELLM INGLGDIMNN KVFYQHPNLM RVLGMHETVM DVMVNVLGGD
KSQIAFPKMV ASCCRFLCYF CRISRQNQKA MFEHLSYLLE NSSVGLAFPS MRGSTPLDVA
AASVMDNNEL ALALEEPDLD KVVTYLAGCG LQSCPVLLAK GYPDIGWNPI EGERYLSFLR
FAVFVNSESV EENASVVVKL LIRRPECFGP DLRGEGGNGL LAAMQEAIRI SENPSRDLPS
QGYKREGDEE EEEEEIVHMG NAIMSFYSAL IDLLGRCAPE MHLIQSGKGE AIRIRSILRS
LVPTEDLVGI ISIPLKLSTV NKDGTVNEPD MSANFCPDHK APMVLFLDRV YGIKDQTFLL
HLLEVGFLPD LRASASLDTV SLSTTEAALA LNRYICSAVF PLLKRCAPLF SGTEHHASLV
DSMLHTIYRL SKGRSLTKAQ RDTIEECLLA ICHHLRPSML QQLLRRLVFD VPLLNEYCKM
PLKLLTNHYE QCWKYYCLPS GMGSYGIAAE EELHLTEKLF WGIFDSLSHK KYDPELFRMA
LPCLSAIAGA LPPDYLDTRI RSTLEKQTSV DPEGNFDPKP VSTANLVLPE KLEYIVSKYA
EHSHDKWAFD KTNNGWKYGV SLDENTKTHP LIRPFKTLTE KEKEIYRWPA RESLKTMLAM
GWSLERTKEG GETILHQREN EKLRSISQSS QGNGYSPAPL DLSNVVLSRE LQGMVEVMAE
NYHNIWAKKK KMELESKGGG SHPLLVPYDT LTAKEKSRDR EKAQELFKFL QVNGIIISRG
LNDMDLDASS MEKRFAFKFL KKILKYVDSA QEFIAHLEAI VTSGKTEKSP HDQEIKFFAK
VLLPLVDQYF TNHCLYFLSS PTKTLSSSGY ASNKEKEMVA SLFCKLAALV RHRISIFGSD
STTMVNCLHI LAQSLDTRTV MKSGSELVKA GLRAFFENAA EDLEKTSENL KLGKFTHSRT
QIKGVSQNIN YTTVALLPVL TSIFEHISQY QFGVDLLLGD VQVSCYRILC SLYSLGTGKN
IYVERQRPAL GECLASLAAA IPVAFLEPSL NHYNPLSVFN TKSARERAIL GMPDTVEEMC
PEIPQLDGLI KEINDLAESG ARYTEMPHVI EVILPMLCNY LSYWWERGSE SVPESAGPFC
TMITSEHLSI ILGNILKIIN NNLGIDEASW MKRIAVYAQP IISKARPDLL KTHFIPTLEK
LKKKAIKIVM EEEQLKADSK TDTQEAELLI LDEFAVLCRD LYAFYPMLIR YVDNNRANWL
KKPDADSDEL FRMVAEVFIL WCKSHNFKRE EQNFVIQNEI NNLAFLTGDT KSKMSKSGGQ
DQERKKSKRR GDLYSIQTSL IVAALKKMLP IGLNMCTPGD QELISLAKTR YSHRDTDEEV
KEHLRNNLHL QEKSDDPAVK WQLNLYKDIL KNDEPSDPEK NVERVQRISA ALYHLEQVEQ
PLRSKKAVWH KLLSKQRKRA VVACFRMAPL YNLPRHRSIN LFLHGYQNYW IETEEYSFEE
KLVQDLATPP KKDEEEEEDT EKKQPDPLHQ IILYFSRNAL TERSCQEEEE EEEEEKEKTF
EEKEMEKQRT LYQQARLHDR GAAEMVLQMI SASKGHTGPM VVETLKLGIA ILNGGNTIVQ
QKMLDYLKEK KDAGFFQSLS GLMQSCSVLD LNAFERQNKA EGLGMVTEEG TLIVRERGEK
VLQHDEFTRD LFRFLQLLCE GHNNDFQNYL RTQMGNTTTV NIIISTVDYL LRLQESISDF
YWYYSGKDVI DESGQRNFSK ALAVTKQIFN SLTEYIQGPC IGNQQSLAHS RLWDAVVGFL
HVFANMQMKL SQDSAQIELL KELLDLLKDM VVMLLSLLEG NVVNGTIGKQ MVDTLVESSS
NVELILKFFD MFLKLKDLTN SDAFKEHDPD GKGIISKKEF QKSMEAQKQY IQSEIEFLLS
CAEADENDMF NYLDFVERFH EPAKDIGFNV AVLLTNLSEH MPNDSRLQSL LEPAESVLNY
FEPYLGRIEI MGGAKKIERV YFEISESSRM QWEKPQVKES KRQFIFDVVN EGGEQEKMEL
FVNFCEDTIF EMQLASQISE TDSAERPEEE EEEESCYVVD IGDDEEEEKS LESPSAFAMA
CAAVKKNVTN FFKMVTVKNL RKQYRKVRKM TVKEMVKVFF SFFWILFVGM FQLFFTIVWG
IFQILWSTVF GGGLVEGAKN IKVTKILGDM PDPTQFGIHD DVTEAEKAEG AEHGIRAELV
QFVKGEKAET DIISDIFGIP TKKEGGSKHG HDAGLGDIAE MLGSDIQSSL ENTVRKKKGL
QLSEIAKEAE AERKVEAEKA DMEDGEKEDK AKEVQSEQLE EGKVKKKKRR HGQKIEKPEA
VMANFFKALE IYQTKMLHYL ARNFYNLRFL ALFVAFAINF ILLFYKVTEE PLDEVEEDSN
LWNTFDEEEE EEGMVFFVLE ESTGYMAPAL RALAVIHTII SFVCVIGYYC LKVPLVVFKR
EKEVARKLEF DGLYITEQPS EDDIKGQWDR LVINTPSFPN NYWDKFVKRK VINKYGDLYG
AERIAELLGL DKNALDFSPV EESEPEEASL LSWLSSIDTK YHIWKLGVVF TDNSFLYLAW
YTTMSILGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV
AFNFFRKFYN KSEDEDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI
VFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG
FETHTLQEHN LANYLFFLMY LINKDETEHT GQESFVWKMY QERCWDFFPA GDCFRKQYED
QLG
//
