ID U3ICD8_ANAPP Unreviewed; 4171 AA.
AC U3ICD8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=FAT atypical cadherin 2 {ECO:0000313|Ensembl:ENSAPLP00000004910.2};
GN Name=FAT2 {ECO:0000313|Ensembl:ENSAPLP00000004910.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000004910.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000004910.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000004910.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8840.ENSAPLP00000004910; -.
DR Ensembl; ENSAPLT00000005534.2; ENSAPLP00000004910.2; ENSAPLG00000005340.2.
DR GeneTree; ENSGT00940000158507; -.
DR HOGENOM; CLU_000042_2_0_1; -.
DR OMA; QRRENCT; -.
DR Proteomes; UP000016666; Chromosome 14.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031589; P:cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0010631; P:epithelial cell migration; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 30.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.60; Cadherins; 31.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF448; FAT ATYPICAL CADHERIN 2; 1.
DR Pfam; PF00028; Cadherin; 26.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 31.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49313; Cadherin-like; 31.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00232; CADHERIN_1; 10.
DR PROSITE; PS50268; CADHERIN_2; 30.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..4171
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021318343"
FT TRANSMEM 3855..3875
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..148
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 149..256
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 363..458
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 459..564
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 565..666
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 715..819
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 820..928
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 925..1031
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1040..1164
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1165..1276
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1272..1365
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1366..1471
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1472..1576
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1577..1674
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1675..1788
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1885..1986
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1987..2087
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2088..2188
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2189..2295
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2296..2397
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2398..2501
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2502..2608
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2609..2714
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2715..2822
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2823..2927
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2928..3029
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3030..3134
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3135..3239
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3240..3349
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3350..3437
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3590..3758
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3761..3798
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3800..3835
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 4021..4042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4025..4042
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3788..3797
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3825..3834
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4171 AA; 458385 MW; 78AEE3F491C1E4FD CRC64;
LTMAEPLLFA VLLVHCTVRE ASCEKGNTSP LHFTHYFYNA TIYENSAPKT YVESYVKMGI
YKTDPEWDIR YRIASGDTTG LFKTEEHVIG DFCFLRIRTR SSNTALLNRE VKDSYLLIIK
ATESTFAYEA WAKVLIHILD RNDLKPLFSP PSYKVSIRED TPLKTVVSTL SATDADAGQN
AEFYYSLNTK SDLFTVHPTT GAVMTMGRLN STHRGRHHLQ VLAVDRMRKI TEGNGFGNLA
SLTIQVEPSA RKPPSISTVK VTPPDSAEDL LYATLSVESG DSEAGIDSVE LVDGDPGRHF
KVIPSYFGST EFMIVSTKEV NWLLYPFGFN LSLQAKDKSK PPLFSPVRVI HIPPAKYVSA
RFEKEVYRVQ LSEFSPAGSQ VVMVKITPVF PNLKYVLRPT PNSTNFKINP HTGLITTVRA
MDFHEQSHFE LEVTTTNSHT STTVSIDIID CNNHAPIFSQ SSYRGAFDEN VPPGTSVLTV
MATDEDEGDN GFVTYTIANQ KSVPFVIDPY SGIISTSKSM DYELMQRWYH LRVWASDWGS
PFRHETEVYI SLVLNNVNDN APVFEKASCS GSIPRDFPVG NPVATVSAID SDELQHIKYE
IKSGNELRHF ELNPISGVIS LRISLRDLPS EQPLFYSLKI TATDGENYAV PTSVNITVVS
QGLPVKMQCE ETGVLKQLTE TIIHSIESQS QGHGQDDETS LNLHLINHNA PKFDDSFPRS
IDIIETVPIN STIADLSAVD PDTGFNGKLV YVISDGNDDS CFTIDLETGL LQVLTPLDHE
RTSFYILNIT VYDLGTPQKS SWKLLAVNVL DTNDNTPKFP QGAYWVVVPE NVATGTTIAQ
LKAEDADTDD NGRVKYSLLT PTDKFAINSV TGEVTVTGAL DRESWPCYVL KIEARDQPKT
GYQLFSVTDL TVTLEDVNDN TPQCLPALNS VKVPEDLPVG TILLFLEAFD PDAGSGGEVR
YSLINDEEMM FHVDKLTGAL RLEKELDYEK KDSYNLTVQV SDSGKPFSRS SLCHLEVNIL
DVNENLYPPR FASFVFKGWV QENSPEGTSV MMVTAKDIDK GKDGEVQYFL REGTGLSIFR
IEKDTGNAAW DIQCASLDLS ALDPSQALSV ILLGTIRTIG PLDREGTSHY WLTVAVSDNG
DPALKSTSRV VIQVLDANDS PPTFPHKLFM VQLPEREASE TPLPVYRLIA SDRDQGQNSQ
VTYTIEEEEE GIFTINPTTG VVFSRKAFPA SEYNILTVKA TDGGSPPLSS HVRLHISWVA
RPGPSSEPLA FDEPHFNFAV METDPVNHMV GVISIEMGPS QVWFNITGGD DDMDFDIEKS
TGSMVIARAL DARKKSSYNL TVEVTDGSTT IKTQVILSAL HRPQFLESHY EVRIPEDTPS
GREILQVSAT DKDKGKGLIY TIHGSVDPKS TRLFQLDPSS GVLTTAEGFS SQPMPQHTLT
VMVRDQEVPI KRNFVRVIIH VENCNLHPPQ FSTIHYEAEV LDSAAVGTEV IQVRALDQDQ
GANAEIHYSL QAGNGEGFFS IDPHSGIITV AQKLDPSKQE RFTLIVKAED QGFPQLKDSA
TVHVRIRPSD RTPPKFPEPE YITEISESTA VGSPLIQVSA TSLSPVSYEI KDGNGDGVFS
MNYQSGLIST QKSLDFEQVS FYQLKVRGTN MAGAFMDTMV LIYVIDENDN VPIFVKPAFT
GWIMENAPSQ TMVLDESNAP LVTHATDADQ DSNALLVYEI LEPEALKYFT VDPSTGTLTS
RADIDYELTP VFHFSVHAHD SGSPSLFASK PAKVTIHVKD VNDSPPVFVK DTYELSVLLP
VHPGMELLSV QAKDADSEVT YSIVEGNLDN AFCIHPLTGL ISILNATGLG SHRELTVRAG
DGLYKSTALV KLNLTQVQGS GLKFDQDVYT ATVMENSTDE KTLTVLGVKG YQLNEPLFYS
LLNGKERFKM IQASGVLQTK GVKFDREIQD MHEVAVEVKD NRKPPRVSQA TVKVYVEDVN
DNPPQFENVP YYTSVQDGTE PGDVLFQVSA TDKDIGNNAA ITYSFAEDYK YFWIDPYLGD
ISLKMPLDYQ ALNKYSLRVI AKDKGEPPLL AEEEVVISVR NKSNPLFQSL YYRVKVPENI
PLYTSILHIQ ARSPEGLRLI YNIVEEDSLK LFSTDFKTGV LTVTGQLDYE LQTKHTFTVR
ATDTALGSFS EARVEVEVED INDNPPVFSQ MIYTASVSES MPAHTPVIQI FASDKDSGRN
KVVSYQILDD GSDATKFFNI DANTGQITTA QALDYEKNQQ FRMKVRAADH GMPPLSSDAL
VIVDVMDIND NPPEFSQLQY EAKVSEMATC GHIVIKVQAL DPDSGDTTRL EYVILSGNDN
RHFTINSTSG IISMFNRCKK DLESSYNLRV SASDGVFKST VPVYINTTNA NKYSPSFRQN
VYEAELAENA EIGTKVIELL AIDPDGGPYG TIDYTIINKL ADEKFSIDNK GHITTLQKLD
RENSTERVIA IKVMAKDGGG KVAFCTVKII LTDENDNPPQ FKASEYTLSI QSNVSKGSPV
IQVLAYDADE GANADVIYSV DSVEDVAEDL VEINAATGVV KVKESLVGLE NRAFNFKVKA
EDGRPPHWNS LVPVNLQIVP REVTLPRFSE PLYTFSASED LPEGSEIGSV KAFAEDPIIY
SLVKGTTTES NKDEVFTLDE QTGALKIKKA VDHETTKWYQ IDVMAHCSHQ ETELVSLVSV
NIQVQDINDN KPVFEADPYK AFVMENMPSG TTVIQVTAND QDTGSDGQVT YSLEAESGNL
RGLFTIDGES GWITTLKELD CETQETYRFY VVATDHGRKV QLSSQTLVEV TVSDENDNAP
QFTSDFYKGS VIENAEPGQV VVTLSTIDAD ISEQNRRVTC YITEGDTLGQ FQVNQIEGEW
TISSKKPLDR EDTEKYLLKV MASDGKFQAT TEVEIFVLDI NDNSPECGQI FYTGRVSEDA
QPGLFILKIS ATDPDVGSNA QITYSLHGPG AEEFRLGPHT GELTTSAPLD REQKPTYHLV
AKATDGGGRS CQADIMLSVE DTNDNAPRFF PSHCAVAVFD NTTTKTPIAV VAARDLDEGP
NAEVIYSLSD SANGHFSIEE TTGVIRLEKP LKDSQHSAFE LTVCATDRGS PEPLSALGTV
TVSVVDLNEY LPVFLAPEYV AMVQEDVAVG TEVLNLSALT RDNTENTEIK YEIVNGNDHG
KFQLNSNTGA LYINGSLDFE ASHEYYLSIE GTRKGSASLS DVTMVVINIT DINDHAPEFI
QDPYFADIRE DAAVGEIILT VSADDLDGAM NNQITYSIVE GNPLGHFAIQ PKSGQISIAK
KIKIDVSQKP KGSQYIQLPA VSDSGIPPLS SSAFINIQVT EQSQYAPSAL PLEIFITTNE
AAFRGGVLGK IHATDRDPHD TLVYTLVAEV PREGRFSVGA TDGKIIAGDK LPHGHYLLNV
TVSDGTFTAS TSVNVHVWCF TQEALDKAVV LHFRHLSPEE FVGDHWRNLQ RFLGNVLVTR
RQNIHMASLQ PAASSDGVDL LLAVGEPHGS LYEPRVLANK ITVSAGEMDQ LVGLRMKKAI
HVPCHGSDCA HRVCKETIQL DPGMMSTYST ARLSVLTPRH SLEQICSCNG TAVRFGGHSY
IWYQHSQAGS WHMHFRLKTH QQHAVVFSAN GTDQAVVNGV PHLGYSCRGS YTGNLSSSRL
VSDGEWHSVF LEVKNTSVRL LIDGLGNASL QLPGTCGISQ GRRDLLFGGL RQPLQSQRLT
RGFRGCLDVL AINGREVVLL PGKGQSKEVV EEVGIKQCCS PTGACSSNPC LNNGMCSETH
GGGYTCICSG LFSGERCELG DSPCDSKPCL HGGTCVLSGS IHCICPSDYQ GDYCTQPIIT
PAIVPTQWAV GPEEIAEIVA GVLGVAILAV AFVLIRKRYR HRAKAHKPVA REDPDLLSKS
EFSKSVGVGT QAVPPIELNI LGDTAHNNLD RATPEQRKAS GTPEFVTFNS ANAPKHRGTI
VCSVAPNLPP AAPPSNSDNE SFVKCTWARE EMVYPAETTY WPPRYLSSDV QEYSHYEIIQ
APPASSSHPP LPPPPPPPAD AEPVALYGGF PFPLDQSNKR APIPPRYSNQ NLEDFLPLGP
VEMGASQCQN EYTAISYYPA QLVQGEGVPY QPEPGYKRVS MRLSVAQPSY ADCEVVGHHQ
PGLRAQPLPP PNYEGSDMVE SDYGSCEEVM F
//
