ID U3IDT8_ANAPP Unreviewed; 1143 AA.
AC U3IDT8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=G protein-coupled receptor 158 {ECO:0000313|Ensembl:ENSAPLP00000005410.2};
GN Name=GPR158 {ECO:0000313|Ensembl:ENSAPLP00000005410.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000005410.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000005410.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000005410.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic
CC cell membrane {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034099}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; U3IDT8; -.
DR STRING; 8840.ENSAPLP00000005410; -.
DR Ensembl; ENSAPLT00000006040.2; ENSAPLP00000005410.2; ENSAPLG00000005836.2.
DR GeneTree; ENSGT00940000155918; -.
DR HOGENOM; CLU_006832_0_0_1; -.
DR OMA; THVCLPC; -.
DR Proteomes; UP000016666; Chromosome 2.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0008047; F:enzyme activator activity; IEA:Ensembl.
DR GO; GO:0160079; F:G protein-coupled glycine receptor activity; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0001956; P:positive regulation of neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0050807; P:regulation of synapse organization; IEA:Ensembl.
DR CDD; cd15293; 7tmC_GPR158-like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR043458; GPR158/179.
DR PANTHER; PTHR32546; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR PANTHER; PTHR32546:SF11; G-PROTEIN COUPLED RECEPTOR 158-RELATED; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1143
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5021378195"
FT TRANSMEM 403..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..654
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 19..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..958
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1013
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1143 AA; 128683 MW; B8A6A6E69504BC9E CRC64;
MALLRLLLLL LLAPRGLGAA ASPGQAAQGR ERAARGRQAV YNHIKSREPP PAPRSRSPES
TILAQRLAEE VPQDVASFLY TGDSRELRRA NCSGRYELAS LAGKSRFTSH PSLHGALDTL
THATNFLNMI LQSNKSREQN LQEDLEWYRA LIRSLLEGDP NISRAAITFS TEPFSSTPQV
FLQASRHESQ ILLQDLSSSA HRLANASVET EWFHSLKRKW RPHLHRKVLN AGPKTLENSW
KRRESFTADK NHIRWSSPYL ECENGNYKPG WLVTLSAAFY GLRPNLLPEF RGVVKVDINL
QKVDIDQCSS EGWFSGTHRC HLNNSECMPI KGLGFVLGAY KCICKTGFYH PNIFSVNSFQ
RKDTDNRFSG GDLSEEVYTC LPCREGCSYC TDDTPCYAQE DKYLRLAIIS FQTLCMLLDF
ISMLVVYHFR KAKSIRASGL VLLETILFGS LLLYFPVVIL YFEPSVFRCV LLRWVRLLGF
ATVYGTVTLK LHRVLKVFLS RTAQRIPYMT GGRVMRMLAV ILLVVFWFLV GWTSAITQNL
ERNIPLIGQG QTSDHLIFNM CLLDRWDYMM AVAEFLFLLW GVYLCYAVRT VPSAFHEPRY
MAVAVHNELI ISAIFHTIRF ILASRLQSDW MLMLFFAHTH LTVTVTVGLL LIPKFSHSSN
NPRDDIATEA YEDELDMGRS GSYLNSSINS AWSEHSLDPE DIRDELKKLY AQLEIYKRKK
MIANNPHLQK KRCSKKGLGR SIMRRITEIP ETVTRQCSRD EKDLLEHSAV KNTSTLKKNP
QDSTSSVKPK EETIKNRVFS LKKSHSTYDH VRDQTGEPNS LTTESTDVIA AENSLLDSLT
GNDVTKKAPE KVEAVSTESV PLVCKSVSAH NLSADKKPLH PRTSVLQKSL SVIASAKEKT
LGLTGKTQSL EESAKSHKSQ QKGKEASRKH SASDKGEHKD SHRKNSTHSE EAKKTHKSGI
MKQQRVAQTP TNPDTGPEPE KNHPSQPKGK SHHKQKTPEG YQQSNQQSSE KVEAATREAQ
EQQVFENEKK QSNSKPQVSP GLKCENFNRY APNICAGEHD ELPPKAVENI NKLVEQKKNA
SSEGNVLSSD SRKPSSYLQQ PSASRAEVCP WEYDTPDLPN AERSVALSNT SAISANKTAT
PRK
//