ID U3IE28_ANAPP Unreviewed; 572 AA.
AC U3IE28;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Heterochromatin protein 1-binding protein 3 {ECO:0000256|ARBA:ARBA00019297};
GN Name=HP1BP3 {ECO:0000313|Ensembl:ENSAPLP00000005500.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000005500.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000005500.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000005500.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; U3IE28; -.
DR STRING; 8840.ENSAPLP00000005500; -.
DR Ensembl; ENSAPLT00000006131.2; ENSAPLP00000005500.2; ENSAPLG00000005878.2.
DR GeneTree; ENSGT00940000155314; -.
DR HOGENOM; CLU_035727_1_0_1; -.
DR OMA; IQNCKER; -.
DR Proteomes; UP000016666; Chromosome 22.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0031491; F:nucleosome binding; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0070828; P:heterochromatin organization; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0097298; P:regulation of nucleus size; IEA:Ensembl.
DR CDD; cd00073; H15; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR005818; Histone_H1/H5_H15.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR15832:SF1; HETEROCHROMATIN PROTEIN 1-BINDING PROTEIN 3; 1.
DR PANTHER; PTHR15832; SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG; 1.
DR Pfam; PF00538; Linker_histone; 3.
DR SMART; SM00526; H15; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51504; H15; 3.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 158..233
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 256..331
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT DOMAIN 339..414
FT /note="H15"
FT /evidence="ECO:0000259|PROSITE:PS51504"
FT REGION 1..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..457
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 63178 MW; 1905C8FBE8651483 CRC64;
MATDLSEAEP VHHKALPLLT GAQLIHTDKL SEKVEDETMP IRRSVNSSSR ETPPKSKPAE
GGEEVKADAE ATSEESASAG EEQENETLPA ASSEAEQPKE PENEGKGETK SSEETKKDEK
DQSKEKEKKV KKTIPAWATL SASQLARAQK QTQMAATSRP KMDAILTEAI KACFQKSGAS
VVAIRKYIIH KYPSLELERR GYLLKQALKR ELERGIIRQV KGKGASGSFV VVSNAGKTVP
KARDRKKSTS ASTPEQQVKL EDILPLAFTR LCEPKEASYS LIKKYVSQYY PKLKVDVRPQ
LLKNALQRAV EKGQLEQITG KGASGTFQLK KSGEKPLLGG TLMEDAILSA IAAMNEPKTC
STTALKKYIL ENHPGTNSNF QVHLLKRTLQ RCEKNGWLEQ ISGKGFSGTF QLCFPYYPSP
GVLYPEKQQD EDSEESDEEE EEESEEEEES EEEESEEEEP PPKKRMQKRP PPKSRSRAPP
MKRRESKPKP RKTPAARSGK AKPPPKVKTP AKKAKPAAPA IKKPSGGSSS KKPAASGRKE
VKPSAKGKPT MRKSLRAKKQ QEHGDWGNKI LN
//
