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Database: UniProt
Entry: U3IFU0_ANAPP
LinkDB: U3IFU0_ANAPP
Original site: U3IFU0_ANAPP 
ID   U3IFU0_ANAPP            Unreviewed;       537 AA.
AC   U3IFU0;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 2.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=T-box transcription factor 5 {ECO:0000313|Ensembl:ENSAPLP00000006112.2};
GN   Name=TBX5 {ECO:0000313|Ensembl:ENSAPLP00000006112.2};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000006112.2, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000006112.2, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000006112.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00201}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR   AlphaFoldDB; U3IFU0; -.
DR   STRING; 8840.ENSAPLP00000006112; -.
DR   Ensembl; ENSAPLT00000006752.2; ENSAPLP00000006112.2; ENSAPLG00000006488.2.
DR   GeneTree; ENSGT00940000156506; -.
DR   HOGENOM; CLU_037025_1_0_1; -.
DR   Proteomes; UP000016666; Chromosome 16.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl.
DR   GO; GO:0003167; P:atrioventricular bundle cell differentiation; IEA:Ensembl.
DR   GO; GO:0060928; P:atrioventricular node cell development; IEA:Ensembl.
DR   GO; GO:0060929; P:atrioventricular node cell fate commitment; IEA:Ensembl.
DR   GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl.
DR   GO; GO:0086054; P:bundle of His cell to Purkinje myocyte communication by electrical coupling; IEA:Ensembl.
DR   GO; GO:0003218; P:cardiac left ventricle formation; IEA:Ensembl.
DR   GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0086019; P:cell-cell signaling involved in cardiac conduction; IEA:Ensembl.
DR   GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
DR   GO; GO:0003197; P:endocardial cushion development; IEA:Ensembl.
DR   GO; GO:0030324; P:lung development; IEA:Ensembl.
DR   GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR   GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0007389; P:pattern specification process; IEA:Ensembl.
DR   GO; GO:0060039; P:pericardium development; IEA:Ensembl.
DR   GO; GO:1903781; P:positive regulation of cardiac conduction; IEA:Ensembl.
DR   GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR   GO; GO:0051891; P:positive regulation of cardioblast differentiation; IEA:Ensembl.
DR   GO; GO:1903598; P:positive regulation of gap junction assembly; IEA:Ensembl.
DR   GO; GO:0072513; P:positive regulation of secondary heart field cardioblast proliferation; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0003163; P:sinoatrial node development; IEA:Ensembl.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR   CDD; cd20189; T-box_TBX4_5-like; 1.
DR   Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR046360; T-box_DNA-bd.
DR   InterPro; IPR036960; T-box_sf.
DR   InterPro; IPR001699; TF_T-box.
DR   InterPro; IPR018186; TF_T-box_CS.
DR   PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11267:SF28; T-BOX TRANSCRIPTION FACTOR TBX5; 1.
DR   Pfam; PF00907; T-box; 1.
DR   PRINTS; PR00937; TBOX.
DR   SMART; SM00425; TBOX; 1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS01283; TBOX_1; 1.
DR   PROSITE; PS01264; TBOX_2; 1.
DR   PROSITE; PS50252; TBOX_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00201};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          74..254
FT                   /note="T-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50252"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        278..294
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  60072 MW;  C7B4025D28F8055B CRC64;
     MEFNKQVGDS AKEARNMADS EEGFGLPTTP ADSEAKELQA DAKQDTQLGA PSKPPTSPQA
     AFTQQGMEGI KVFLHERELW LKFHEVGTEM IITKAGRRMF PSYKVKVTGL NPKTKYILLM
     DIVPADDHRY KFADNKWSVT GKAEPAMPGR LYVHPDSPAT GAHWMRQLVS FQKLKLTNNH
     LDPFGHIILN SMHKYQPRLH IVKADENNGF GSKNTAFCTH VFPETAFIAV TSYQNHKITQ
     LKIENNPFAK GFRGSDDMEL HRMSRMQSKE YPVVPRSTVR QKVSSNHSPF SGETRVLSAS
     SNLGSQYQCE NGVSSTSQDL LPPANPYPIS QEHSQIYHCT KRKDEECSTT EHPYKKPYME
     TSPAEEDPFY RSSYPQQQGL NTSYRTESAQ RQACMYASSA PPTDPVPSLE DISCNTWPSV
     PSYSSCTVSA MQPMDRLPYQ HFSAHFTSGP LMPRLGSVAN HTSPQIGDTH SMFQHQTSVS
     HQPIVRQCGP QTGIQSPPSS LQPAEFLYSH GVPRTLSPHQ YHSVHGVGMV PEWSENS
//
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