ID U3IGJ7_ANAPP Unreviewed; 309 AA.
AC U3IGJ7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Endoribonuclease LACTB2 {ECO:0000256|ARBA:ARBA00019428};
DE AltName: Full=Beta-lactamase-like protein 2 {ECO:0000256|ARBA:ARBA00032142};
GN Name=LACTB2 {ECO:0000313|Ensembl:ENSAPLP00000006369.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000006369.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000006369.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000006369.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Endoribonuclease; cleaves preferentially 3' to purine-
CC pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage
CC product contains a free 3' -OH group. Has no activity with double-
CC stranded RNA or DNA. Required for normal mitochondrial function and
CC cell viability. {ECO:0000256|ARBA:ARBA00002153}.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily.
CC Glyoxalase II family. {ECO:0000256|ARBA:ARBA00006759}.
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DR AlphaFoldDB; U3IGJ7; -.
DR STRING; 8840.ENSAPLP00000006369; -.
DR Ensembl; ENSAPLT00000007013.2; ENSAPLP00000006369.2; ENSAPLG00000006753.2.
DR GeneTree; ENSGT00390000001710; -.
DR HOGENOM; CLU_048478_1_2_1; -.
DR OMA; GDHVMAW; -.
DR Proteomes; UP000016666; Chromosome 2.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR CDD; cd07722; LACTB2-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047921; LACTB2-like_MBL-fold.
DR InterPro; IPR041516; LACTB2_WH.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23131; ENDORIBONUCLEASE LACTB2; 1.
DR PANTHER; PTHR23131:SF0; ENDORIBONUCLEASE LACTB2; 1.
DR Pfam; PF17778; BLACT_WH; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 30..199
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 309 AA; 34642 MW; 4E36362606AE50BA CRC64;
MVSLLPRIER LSSRVVRVLG CNPGPMTLQG TNTYLVGTGH RRILIDTGEP AVPEYIGCLK
QALSEFNISI QEILVTHWHH DHTGGIPDIC KNIPSDSEYR ICKLPRVPDR EEIIGEGRHK
YSYLKDGDVV QTEGATLRVL HTPGHTDDHM ILHLEEENAI FSGDCILGEG TTVIEDLYDY
MKTLKRLLEM KPDLIYPGHG PVVRDANTRI QGYISHRTAR EKQILNVFQK NVGKSFTSSE
LLSMVYKDIP ENLLLAAEKN LLVHLKKLEK EGKVCKLWVV GCRGVRTVIF ISIFCVQGGG
RGKGQSLII
//
