ID U3IH64_ANAPP Unreviewed; 332 AA.
AC U3IH64;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=3-dehydrosphinganine reductase {ECO:0000256|ARBA:ARBA00026112};
DE EC=1.1.1.102 {ECO:0000256|ARBA:ARBA00026112};
GN Name=KDSR {ECO:0000313|Ensembl:ENSAPLP00000006586.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000006586.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000006586.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000006586.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|RuleBase:RU000363}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; U3IH64; -.
DR STRING; 8840.ENSAPLP00000006586; -.
DR Ensembl; ENSAPLT00000007232.2; ENSAPLP00000006586.2; ENSAPLG00000006943.2.
DR GeneTree; ENSGT00940000156961; -.
DR Proteomes; UP000016666; Chromosome 2.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0047560; F:3-dehydrosphinganine reductase activity; IEA:Ensembl.
DR GO; GO:0006666; P:3-keto-sphinganine metabolic process; IEA:Ensembl.
DR GO; GO:0030148; P:sphingolipid biosynthetic process; IEA:Ensembl.
DR CDD; cd08939; KDSR-like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR045022; KDSR-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43550; 3-KETODIHYDROSPHINGOSINE REDUCTASE; 1.
DR PANTHER; PTHR43550:SF3; 3-KETODIHYDROSPHINGOSINE REDUCTASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT COILED 62..111
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 332 AA; 36244 MW; 8557CF61F681515A CRC64;
MLLLAAAFVV GFVLLLYMVS PLISPKPLKL PGAHVVVTGG SSGIGKCIAI ECYKQGAFIT
LIARDENKLL QTKKEIEKYS VNDKQVVLCI SVDVSKDYEQ VENVLKQAQE KLGPVDLLVN
CAGTSVTGKF EAIEVNSFER LMAVNYLGSV YPSRAVISTM KERRMGRIVF VSSQAGQLGL
FGYTAYSPTK FALRGLAEAL QMEVKPYNIY VTVAYPPDTD TPGFAEESKT KPLETKLISE
TSSVCQAEQV ARVIVKDAIQ GNFNSSVGSD GYMLSILTSG MSPVTSITEG LQQVVCMGIF
RIIGLFYLGS FDSIVRRCMM QREKSESTDK TE
//
