ID U3IHP1_ANAPP Unreviewed; 683 AA.
AC U3IHP1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Rhophilin-2 {ECO:0000256|ARBA:ARBA00044090};
DE AltName: Full=GTP-Rho-binding protein 2 {ECO:0000256|ARBA:ARBA00044320};
GN Name=RHPN2 {ECO:0000313|Ensembl:ENSAPLP00000006763.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000006763.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000006763.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000006763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RHPN family.
CC {ECO:0000256|ARBA:ARBA00010369}.
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DR AlphaFoldDB; U3IHP1; -.
DR STRING; 8840.ENSAPLP00000006763; -.
DR Ensembl; ENSAPLT00000007412.2; ENSAPLP00000006763.1; ENSAPLG00000007093.2.
DR GeneTree; ENSGT00940000153837; -.
DR HOGENOM; CLU_006514_1_0_1; -.
DR OMA; HTAMSQA; -.
DR Proteomes; UP000016666; Chromosome 12.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003094; P:glomerular filtration; IEA:Ensembl.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09249; BRO1_Rhophilin_2; 1.
DR CDD; cd11634; HR1_Rhophilin-2; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.280; alix/aip1 like domains; 1.
DR Gene3D; 1.10.287.160; HR1 repeat; 1.
DR InterPro; IPR004328; BRO1_dom.
DR InterPro; IPR038499; BRO1_sf.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR036274; HR1_rpt_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR049603; Rhophilin-2_HR1.
DR InterPro; IPR047138; RHPN1_2.
DR InterPro; IPR047902; RHPN2_BRO1.
DR PANTHER; PTHR23031; RHOPHILIN; 1.
DR PANTHER; PTHR23031:SF5; RHOPHILIN-2-RELATED; 1.
DR Pfam; PF03097; BRO1; 1.
DR Pfam; PF02185; HR1; 1.
DR SMART; SM01041; BRO1; 1.
DR SMART; SM00742; Hr1; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF46585; HR1 repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51180; BRO1; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51860; REM_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01207};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 26..100
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 111..460
FT /note="BRO1"
FT /evidence="ECO:0000259|PROSITE:PS51180"
FT DOMAIN 522..583
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 683 AA; 76928 MW; C11FB22FF4CF921A CRC64;
MTDALPPRGC QAAEPAEDSY FRKGCNPLAE TGRSKLQNQR AVLNQQILRA VRMRAGAENL
LRATTNNKVR EQVLLELSFV NSDLQILKEE LEGLNISVEV YQNTEETFSI PLVPLGLKET
KEVDFTLPLK DFILEHYSED SSEYEDEIAD LMDLRQACRT PSRDEAGIEM LISYFLQLGY
VENRFFPPTR HMGILFTWYD SFTGVPVCQQ NLLLEKASIL FNIGALYTQI GTRCNRQTQN
GLENAVDAFQ RAAGVLNYLK ETFTHTPSYD MSPAMLNVLV KMMLAQAQEC AFEQMSLPGI
RNEFFTLVKM TQEAAKVGEV YMMVNTAMTQ EPVKENIPYS WSKLVQIKSD HYKALAHYFV
ATILCDHELQ SSDDEDQQEK ALSQLYDHMP EGLMALTVLK DKVQRKQLGK AHLRKAVVYH
EEALRVCGLC KKLRNIDVLQ EVLTAAHKRS LLKYAQQEKE DDFLSLIQTP DILPKTEHKV
ETITPQFSKV KVKDFFHRLG PLSVFSAKQR WTAPRTIRFH CEAGELGFSL KGGSPVQIYC
LDPACSAASM GLKEGDYIVS VGGVDCKWLG VNEVLEKFKS VGEQPIEFEV ISCQDTTASM
HSKSATYSVG MQKTYSLICL AMEEDKIDQT KKAPLKLPFL SWGTKNRQKA ASTLCLPSAV
AGSSQTKKKL SPFALLNTES SLY
//
