ID U3IHX7_ANAPP Unreviewed; 406 AA.
AC U3IHX7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=SH3 domain containing GRB2 like 2, endophilin A1 {ECO:0000313|Ensembl:ENSAPLP00000006849.2};
GN Name=SH3GL2 {ECO:0000313|Ensembl:ENSAPLP00000006849.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000006849.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000006849.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000006849.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the endophilin family.
CC {ECO:0000256|ARBA:ARBA00006697}.
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DR AlphaFoldDB; U3IHX7; -.
DR STRING; 8840.ENSAPLP00000006849; -.
DR Ensembl; ENSAPLT00000007500.2; ENSAPLP00000006849.2; ENSAPLG00000007190.2.
DR GeneTree; ENSGT00940000160529; -.
DR HOGENOM; CLU_047887_0_0_1; -.
DR OMA; EYIPKPR; -.
DR Proteomes; UP000016666; Chromosome Z.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:1905604; P:negative regulation of blood-brain barrier permeability; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR CDD; cd07613; BAR_Endophilin_A1; 1.
DR CDD; cd11803; SH3_Endophilin_A; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035824; Endophilin_A_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF50; ENDOPHILIN-A1; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..303
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 344..403
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 297..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 46842 MW; 79FFC6EAA191B6B7 CRC64;
MVWMSSVSSR RLGLRDLCNR VFLFVCLFEC FTNLRKKKNQ QRFPRETWWP KLMLLLNVFF
LFFFLKKLQK VSEKVGGAEG TKLDDDFKEM ERKVDVTSRA VMEIMAKTIE YLQPNPASRA
KLSMINTMSK IRGQEKGPGY PQAEALLADA MLKFGRELGE ECNFGPALVD VGEAMKELSE
VKDSLDMEVK QNFIDPLQNL HDKDLREIQH HLKKMEGRRL DFDYKKKRQG KLPDEELRQA
LEKFDESKEI AESSMFNLLE MDIEQVSQLS ALVQAQLEYH KQATQILQRV TSKLEDRIKE
ASSQPKREYQ PKPRMSLDFT TGDNTQHNGG ISHATTPKPA GAHMDQPCCR ALYDFEPENE
GELGFKEGDI ITLTNQIDEN WYEGMLHGQS GFFPINYVDI LVPLPN
//
