ID U3IIA1_ANAPP Unreviewed; 260 AA.
AC U3IIA1;
DT 05-JUN-2019, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Pro-thyrotropin-releasing hormone {ECO:0000256|PIRNR:PIRNR001795};
GN Name=TRH {ECO:0000313|Ensembl:ENSAPLP00000006973.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000006973.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000006973.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000006973.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems.
CC {ECO:0000256|PIRNR:PIRNR001795}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000256|ARBA:ARBA00010437,
CC ECO:0000256|PIRNR:PIRNR001795}.
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DR AlphaFoldDB; U3IIA1; -.
DR STRING; 8840.ENSAPLP00000006973; -.
DR Ensembl; ENSAPLT00000007624.2; ENSAPLP00000006973.1; ENSAPLG00000007356.2.
DR GeneTree; ENSGT00390000016951; -.
DR OMA; HPGKRFT; -.
DR Proteomes; UP000016666; Chromosome 13.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR InterPro; IPR008857; TRH.
DR PANTHER; PTHR17530; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR PANTHER; PTHR17530:SF2; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|PIRNR:PIRNR001795};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001795};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR001795}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT CHAIN 24..260
FT /note="Pro-thyrotropin-releasing hormone"
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT /id="PRO_5019622105"
FT REGION 88..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 260 AA; 30236 MW; 00739505B1E4E675 CRC64;
MLSIQLPLLL LCLTLSGVCL NGGQPLPEAS ENMGRRPLDN ILQRSESFIL QSVLKKAEKK
EEMNKELNAP LPEWLSKRQH PGKRYISDLE KRQHPGKRDV KEEASYGDIQ KRQHPGKREV
EDDLASYLEL KKRQHPGRRS LWDQHVDIPS ARLTYLNVLS KRQHPGRGYL MHKHQHPSKR
GWNDELDISD HDGEKRQHPG KRHWDTDNPD YAGPCDLQES STCNTGSLWV DLPEKFSKDR
VEEKRQHPGR RSTWESETEE
//
