ID U3IIY3_ANAPP Unreviewed; 880 AA.
AC U3IIY3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Complement C5 {ECO:0000313|Ensembl:ENSAPLP00000007205.2};
GN Name=C5 {ECO:0000313|Ensembl:ENSAPLP00000007205.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000007205.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000007205.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000007205.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; U3IIY3; -.
DR STRING; 8840.ENSAPLP00000007205; -.
DR Ensembl; ENSAPLT00000007863.2; ENSAPLP00000007205.2; ENSAPLG00000007514.2.
DR GeneTree; ENSGT00940000155670; -.
DR HOGENOM; CLU_001634_4_2_1; -.
DR OMA; YKRIIAC; -.
DR Proteomes; UP000016666; Chromosome 18.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0005579; C:membrane attack complex; IEA:Ensembl.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0010760; P:negative regulation of macrophage chemotaxis; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:0010575; P:positive regulation of vascular endothelial growth factor production; IEA:Ensembl.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR048843; C5_CUB.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF83; COMPLEMENT C5; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF21309; C5_CUB; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00643; C345C; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..880
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019791450"
FT DOMAIN 736..880
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 880 AA; 98721 MW; 774C527C3AC0564B CRC64;
MWFIRRVFLC LIFLGICVTA PLEVQVVKDI FLNVYVPYSV VRGEQIELKG SVYNHRASSI
KFCVKIAVGD GICSFGGSAT TGSRIRGCNL KYLGSSSSSP FMFRILPLEL GLHTINFTLL
TDGNSETVVK TLRVMPEGIK KELHAGFTLD PQGVYGAVKR RQEFRYKIPL NLVPKTKIDR
SVSVKGHLMG EVIATVLNPS GISILTNLPK GSAEAELMSI APLFYVFHYL EASDNWHILG
SKTLTSRTEM RRKMKEGIVS VLSYRNADFS YSMWKNGQAS TWLTAFALRI LGQVNQYINL
DQISVCNSLL WLIDNCQMPD GSFNEFSDYQ PVKLQGTLPR EAKEKSLYLT AFSIIGIEKS
MKICPTQKIH DAKNKAGDYL MKNAESAQSP FTMAIISYAL ALVDLNHQSS RLLFSALKKE
ASVIGEPPIY RFWKDSLKTL DHPTPNSVTA QMVETTAYAL LTALLRGDKN YANPIIKWLS
EEQRYGGGFY STQDTINALE ALTEYSLLVK RLNLDMSVKV AYKNYGDLHL FKLTEENFVG
RTLTVPLEDD IYVSTGSSTG IATVNVRTVY NLIGTSEESC NFELKIVPKR DDGYRIEDGG
PLGRIEACAK YKPSTREPQS GSAHAVMDIG LVSGLEANIE DLNTLASGVD QLIADYEIID
GHVVIQIDSV PADSFLCVGF RISELFHVGM RNPATFTVYE YHAPDKRCTI FYNPYGDEKL
VRLCEGNECK CMEAECSRIQ GRLDQSITAD IRREAACQND IAYVYKVNIL SRREEGHFVK
YSATILDLYK RGQAFAEKNN EITFVKKKTC TDVELSPGEQ YLIMGKEALK ISIGYSFRFQ
YPLDSSTWIE WWPSNTACTF CQEFLNRMED FVEDLIISGC
//
