ID U3IJD0_ANAPP Unreviewed; 620 AA.
AC U3IJD0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Protein smoothened {ECO:0000256|ARBA:ARBA00035037};
GN Name=SMO {ECO:0000313|Ensembl:ENSAPLP00000007352.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000007352.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000007352.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, cilium {ECO:0000256|ARBA:ARBA00004138}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR AlphaFoldDB; U3IJD0; -.
DR STRING; 8840.ENSAPLP00000007352; -.
DR Ensembl; ENSAPLT00000008014.2; ENSAPLP00000007352.2; ENSAPLG00000007726.2.
DR GeneTree; ENSGT00940000157206; -.
DR HOGENOM; CLU_1087877_0_0_1; -.
DR OMA; WLAYAWH; -.
DR Proteomes; UP000016666; Unassembled WGS sequence.
DR GO; GO:0005901; C:caveola; IEA:Ensembl.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0004862; F:cAMP-dependent protein kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:0005113; F:patched binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0060242; P:contact inhibition; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd15030; 7tmF_SMO_homolog; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR035683; SMO_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF35; SMOOTHENED HOMOLOG; 1.
DR Pfam; PF01534; Frizzled; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM01330; Frizzled; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..326
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 497..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 69188 MW; C4370FAC11BDEF39 CRC64;
KCTPDRFPEG CPNEVQNIKF NSSGQCEAPL VRTDNPKSWY EDVEGCGIQC QNPLFTEKEH
REMHVYIAAF SSVTIFCTFF TLATFVADWR NSNRYPAVIL FYVNACFFVG SIGWLAQFMD
GARDEIVCRA DGTMRLGEPT SNETLSCVII FVIVYYSLMS GVIWFVMLTY AWHTSFKALG
TTYQPLLGKT SYFHLITWSI PFVLTVAILA VAQVDGDSVS GICFVGYKNY RYRAGFVLAP
IGLVLIVGGY FLIQGVMTLF SIKSNHPGLL SEKAASKINE TMLRLGIFGF LAFGFVFITF
GCHFYDFFNQ AEWERSFREY VLCEANVTIA TQTNKPIPEC EIKNRPSLLV EKINLFAMFG
TGISMSTWVW TKATLLIWKR TWCRLTGQSD DQPKRIKKSK MIAKAFSKRK ELLRDPGREL
SFSMHTVSHD GPVAGLAFDI NEPSADVSSA WAQHVTKMVA RRGAILPQDV SVTPVATPVP
PEERANLWVV EADVSPELQK RSRKKKRRKK KKDEVCPGPE HHAGGSVDPP PSSSTVPRLP
RLPLQPCGVA GGPWDGRNPR AIVPHLISNP FCPENGSLED EESPGPSGGC WTWGRRPGLA
PIHSRTNLVD AELLDADSDF
//
