ID U3IK56_ANAPP Unreviewed; 1508 AA.
AC U3IK56;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Transient receptor potential cation channel subfamily M member 2 {ECO:0000313|Ensembl:ENSAPLP00000007628.2};
GN Name=TRPM2 {ECO:0000313|Ensembl:ENSAPLP00000007628.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000007628.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000007628.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000007628.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC
CC subfamily. TRPM2 sub-subfamily. {ECO:0000256|ARBA:ARBA00009501}.
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DR STRING; 8840.ENSAPLP00000007628; -.
DR Ensembl; ENSAPLT00000008292.2; ENSAPLP00000007628.2; ENSAPLG00000007910.2.
DR GeneTree; ENSGT00940000156404; -.
DR HOGENOM; CLU_001390_0_2_1; -.
DR OMA; EFLIYEP; -.
DR Proteomes; UP000016666; Chromosome 9.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0015278; F:calcium-release channel activity; IEA:Ensembl.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0072571; F:mono-ADP-D-ribose binding; IEA:Ensembl.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
DR GO; GO:0071415; P:cellular response to purine-containing compound; IEA:Ensembl.
DR GO; GO:0071502; P:cellular response to temperature stimulus; IEA:Ensembl.
DR GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
DR GO; GO:0051289; P:protein homotetramerization; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR GO; GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
DR GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IEA:Ensembl.
DR Gene3D; 3.40.50.450; -; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF2; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 2; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 760..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 902..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..964
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1030..1052
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1359..1503
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1508 AA; 173047 MW; F4B63D4FEE2539E2 CRC64;
MAVHGRHSKV LPSELNKVCP EREDSSSVHP MKMSDFEVVP NLQQSSSSIS RSRRKAHFPS
GNNEKENLIS WIPENIRKKE CVHFVESSQT SDSGRTVCEC GYLREQHLED AVKTPLFLGK
EWDPRRHIQE MPTDAFGDIR FAGLGQKMGK YVRVSSDTPP RVIYHLMTQH WGLDAPNLLI
SVTGGAKNFI MKPRLKNIFR QGLVKVAQTT GAWIITGGSH AGVMKQVGEA VRDFILNCSY
KEAEIVTIGI ATWGTVYNRD SLICPMGGFP AEYVLDEENQ GSLSCLDSNH SHFILVDDGT
HGRYGVEIPL RTRLEKFISE QTKVKGGVAI KIPIVCVVLE GGPGTLDTIY NAITNGTPCV
VVEGSGRVAD VIAQVANLPV PKITIALIRK KLSVLFHDTY ELFTEGKLVE WTKKIQDIVR
SQHLLTIFRE GKYGQQDVDV AILQALFKAS QNQDHFGREN WDHQLKLAVA WNRVDIARSE
IFTDDHEWKP TDLHPVMAAA LISNKPEFVK LFLEQGVRLK EFVTWDTLIY LYNNMASSCL
FHSKLQKVLL EETENTAGSK MPRIQLHHVS QVLRELLGHS TQPLYPKPKH VERPRLSIPV
PHIKLNVHGS SLRSLYKRSS GRVAFSMDPV RDLLIWAVVQ NRQELAEIIW AQSQDCMVAA
LACSKILKEL AKEEEDTDTT DEMLALAEQY ENKAIGVFTD CYRKDEERAQ KLLIRVSEAW
GKTTCLQLAL EAKNMNFVAH GGVQAFLTKV WWGKLCIDNG LWRVIACMLF FPLLYTSLIT
FREKKLQPMN CLTRFRAFFT APVVIFHMNI LSYFTFLLLF AYVLMVDFQP LPSWWEYLIY
FWLFSLVCEE TRQLLYDPDG LGVLKMASLY FKDFWNKLDV CAIVVFITGL TCRLIPSTLY
PGRIILSLAF IIFCLRLMHI FTVSRTLGPK IIIVKRMMKD VFFFLFLLAV WVVSFGVAKQ
AILIHNEERV EWLFRGVVYH SYLTIFGQIP SYIDGVNFNI DQCSPNGTDP YKPKCPETNE
DNKKPIFPEW LTVILLCLYL LFTNILLLNL LIAMFNYTFQ QVQAHTDQIW KFQRHNLIEE
YHGRPPAPPP FILLNHLQLL VRRVLLCRPA MRHKQLKEKL EKNEEAALLS WEMYLKENYL
QHQQCQEKQN TEQKIRDIAQ RVDVLAELLD LDRVKRTGLV EQRLIALEDQ VHQSAKALRW
IMQALQGNGF TSEEDMPLLA SSRTSEVKEL DLEEKPEEKQ PPYHVLSRNL IYPGSHIIRF
PVPDEKVPWE VDFQLYDPPA YSADHKDTAV QDPFNLSLES LLKINYNAMD GLIDRQSFHG
LYAVQDGLPL NPMGRTGLRG RGRLHSFGPN HALHPVVTRW RRNLDGSIIR KSLKKMLEVL
VAQYPLSDVW ALPGGSLEPG EMLPLKLKWV LRREFWPQFQ NLLKQGTEIH KGYLDDPRNT
DNAWVETVAV SIHFDSQNDV QMKRLNSFLQ GCDPELCIRW QVLDRRMPLH ANHKLLLYKV
STLLGAYY
//
