ID U3ILJ8_ANAPP Unreviewed; 1338 AA.
AC U3ILJ8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Dispatched RND transporter family member 3 {ECO:0000313|Ensembl:ENSAPLP00000008120.2};
GN Name=DISP3 {ECO:0000313|Ensembl:ENSAPLP00000008120.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000008120.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000008120.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000008120.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8840.ENSAPLP00000008120; -.
DR Ensembl; ENSAPLT00000008792.2; ENSAPLP00000008120.2; ENSAPLG00000008411.2.
DR GeneTree; ENSGT00940000157931; -.
DR HOGENOM; CLU_007038_0_0_1; -.
DR OMA; RWDYSRT; -.
DR Proteomes; UP000016666; Chromosome 22.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0045834; P:positive regulation of lipid metabolic process; IEA:Ensembl.
DR GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IEA:Ensembl.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR042480; DISP3.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR46687; PROTEIN DISPATCHED HOMOLOG 3; 1.
DR PANTHER; PTHR46687:SF1; PROTEIN DISPATCHED HOMOLOG 3; 1.
DR Pfam; PF03176; MMPL; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 673..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1129..1147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1153..1174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1235..1261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1267..1290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1302..1324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..559
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 161..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 747..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1338 AA; 147970 MW; 4BE4E14BC0695A97 CRC64;
MDTEDDPLLQ DSWLDEEDEE VAFSSRKRQE GALLCGKSPC RARPLRVTLP ATGFWNIVGW
IFTNPYCAGF ILFLGCAIPA VLAVVMFLHY PALDIDISYN AFEIRNHESS QRFDALALAL
KSQFGSWGRN RRDLADFTSE TLQRLIFEQL QQLHLNASHL GGGARAKRST PQGRTSPQKP
RAHLNPGNQT SRAERGAPRW DYSNTYISAN TQTHAHWRIE LIFLARGDAE NNIFTTERLV
TIHEVERKIM DHPRFREFCW KPHEVLKDLP LGSYSYCSPP SSLMTYFFPT ERGGKIYYDG
MGQDLADIQG SLELAMTHPE FYWYVDEGLS AENMKSSLLR SEILFGAPLP NYYSVEDRWE
EQRRKFQSFV VTYVAMLAKQ STSKVQVLYG GTDLFDYEVR RTFNNDMLLA FISSSCIAVL
VYILTSCSVF LSFFGIASIG LSCLVALFLY HVVFGIQYLG ILNGVAAFVI VGIGVDDVFV
FINTYRQATH LKDVQLRMIH TIQTAGKATF FTSLTTAAAY AANIFSQIPA VHDFGLFMSL
IVSCCWVAVL FIMPAALGIW TLYVSPLESS CQTSCSQKCT KKSALHLAED LFIASEATSR
AGRETLPYLD DDIPLLSVEE EPVSLEMGDV PLVSVMPENL QLTVEKSSRG HLIAHLQELL
EHWVLWSAVK SRWVIVGLFL VVLLLSIFFA SRLRPASRAP VLFRPDTNIQ VLLDLKYNLS
AEGISCITCS GLFQEKPHSL QNNIRTSLEK KKRGSGSPWG SKGSISDTGQ QDLQGTVYIS
KSRSKGRPAI YRFSLNASVP APWQMVSPGD GEVPSFQVYR VPFGNFTRKL TACVSTVGLL
KQTSPRKWMM TTLSCDTKRG WKFDFSFYVA AKEQQRTRKL YFAQSHKPPY HGRVCVAPPG
CLLSSSPDGP TKGILYVPSE KAAPKAKLSA TSGFNPCMNT GCGKPAVRPL VDTGAMVFVV
FGIRGINRTG RSDNHVIGDM GSVIYDDSFD LFKEIGNLCR LCKAIASNTE LVKPGGAQCL
PSGYSISSFL QMLHPECKNI PEPNLLPGQL SHGAVGVKDG KVQWISMAFE STTYKGKSSF
QTYADYLKWE TFLQQQLQLF PEGSALRHGF QTCEHWKQIF MEIIGVQSAL YGLILSLVIC
VAAVAVFTTH ILLLLPVLLS ILGVVCLVVT IMYWSGWEMG AVEAISLSIL VGSSVDYCVH
LVEGYLLAGE NLPLHHTEDP TACRQWRTIE AVRHVGVAIV SSAVTTGIAT VPLFFCIIAP
FAKFGKIVAL NTGVSILYTL TVSTALLSIM GPGTFTRSRT SCLKAVAGVL LTGLLGLCIC
LALLKSGFNI PLPNGTAL
//
