ID U3IMY1_ANAPP Unreviewed; 1974 AA.
AC U3IMY1;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=EMAP like 5 {ECO:0000313|Ensembl:ENSAPLP00000008604.2};
GN Name=EML5 {ECO:0000313|Ensembl:ENSAPLP00000008604.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000008604.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000008604.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000008604.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR STRING; 8840.ENSAPLP00000008604; -.
DR Ensembl; ENSAPLT00000009286.2; ENSAPLP00000008604.2; ENSAPLG00000008892.2.
DR GeneTree; ENSGT00940000156613; -.
DR HOGENOM; CLU_001930_0_0_1; -.
DR Proteomes; UP000016666; Chromosome 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF16; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 3.
DR Pfam; PF00400; WD40; 11.
DR SMART; SM00320; WD40; 28.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF50960; TolB, C-terminal domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 4..48
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 250..265
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 330..354
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 381..461
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 404..435
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 663..715
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 899..929
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1234..1266
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1344..1407
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1702..1736
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1746..1826
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 1778..1819
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 610..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1276..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..632
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1974 AA; 219854 MW; 452F93F3F9FCBF45 CRC64;
MADRSAPGCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR EHRQKFYLGH
QDDIISLALH PERVLVATGQ VGKEPYICVW DSYTVQTVSV LKDVHTHGIA CLAFDLDGQR
LVSVGLDSKN TVCVWDWRKG KLLSMAPGHT DRIFDISWDL YQPNKLVSCG VKHIKFWSLC
GNSLTPKRGV FGKTGDLQTI LCLACARDEV TYSGALNGDI YVWKGINLVR TIQGAHAAGI
FSMNACEEGF ATGGRDGCVR LWDLNFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
QDSEIFEIVV HERNKPFLIM QGHCEGELWA LAVHPTKPLA MTGSDDRSVR IWSLIDHALI
ARCNMEEPIR CAAVSTDGIH LALGMKDGSF TVLRVRDMTE VVHIKDRKEA IHELKYSPDG
NFLAVGSNDS SVDIYGVVQR YKKIGECIGS LSFITHMDWS SDSKYLQTND GNGKRLFYRM
PSGKEVTSKE ELKGVQWASW TCVSGVEVNG IWPKYSDIND INSVDANFIG QVMVTADDYG
IVKLFRYPCL RKGAKFKKYL GHSAHVTNVR WSHDHQWVVS IGGADHSVFQ WKFVPDRKLK
DSLHIAPQES LVDSNSDESD SDQSDVPELD SEIEQETQIT YRRQVYKEDL PQLKEQCKEK
RKSAASKRRE RAPGNSIRLH FVHGYRGYDC RSNLFYTQTG EIVYHVAAVG VVYNRQQNTQ
RFYLGHDDDI LCLAIHPLKD YVATGQVGRD SSIHIWDTET IKPLSVLKGY HQYGVCAVDF
SADGKRLASV GIDDNHTIVL WDWKKGEKLS AVRGSKDKIF VVKINPYMPE KLITVGIKHL
KFWRRAGGGL IGRKGCIGAM GRTDTMMCAV YGWTEEMAFS GTSTGDVCIW RDVFLIKTVK
AHDGPVFSMH ALEKGFVTGG KDGVVALWDD TFERCLKTYA IKRAALAPGS KGLLLEDNPS
IRAISLGHGH ILVGTKNGEI LEVDKSGPIT LLVQGHMEGE VWGLATHPHL PICATVSDDK
TLRIWDLSPS HCMLAVRKLK KGGRCCCFSP DGKALAVGLN DGSFLIVNAD TLEDLVSFQH
RKDVISEIRF SPGAGKYLAV ASCDNFVDIY NVMSSKRVGI CKGASSYITH MDWDIRGKLL
QVNTGAKEQL FFEAPRGKKQ TIPTLEVEKI GWASWTSVLG SCCEGIWPII GEVTDVTASC
LTSDSKVLAT GDDFGFVKLF RYPAKGKFGK FKRYVAHSTH VTNVRWTYDD SLLVTVGGAD
TSLMLWTYEM EGHRDTRQCD SEESDLDSEE DGGYDSDVTR ENEINYTIKA LSTNIRPMFG
IKPHLQQKEP TLDERQGVVR PPVSRALPQP EKLQTNNVGK KKRPIEDLIL ELVFGYRGKD
CRNNVHYLND GADVIYHTAS IGILYNVATG SQSFYQEHND DILCLTVNQH PKFTNIVATG
QVGDSADMSA TAPSIHVWDA MNKQTLSVLR CYHSKGVCSV SFSATGKLLL SVGLDPEHTI
TIWKWQEGAK IASRAGHNQR IFVAEFRPDS DTQFVSVGVK HVRFWTLAGR ALLSKKGLLS
SIEDARMQTM LSVAFGANNL TFTGTISGDV CVWKDHVLIR IVAKAHNGPV FTMYTTLRDG
LIVTGGKERP SKEGGAVKLW DQELKRCRAF RLETGQMTDC VRSVCRGKGK ILVGTRNAEI
IEVGEKNAAC NILINGHMDG PIWGLATHPS RDFFLSAAED GTVRLWDIAE KKMLNKVSLG
HAARTVCYSP EGDMVAIGMK NGEFIILLVT SLKIWGKKRD RRSAIQDIRF SPDSRYLAVG
SSENAVDFYD LTLGPTLNRV SYCKDIPSFV IQMDFSADSC YLQVSTGSYK RQVYEVPSGK
QLVDQAVIDR ITWATWTSVL GDEVIGIWSR HAEKADVNCA CVSHSGINLV TGDDFGMVKL
FDFPCPEKFA KHKRFLGHSA HLTNIRFTSG DRYVVSAGGD DCSLFVWKCV HMPH
//