ID U3INH5_ANAPP Unreviewed; 834 AA.
AC U3INH5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Complement C7 {ECO:0000313|Ensembl:ENSAPLP00000008798.2};
GN Name=C7 {ECO:0000313|Ensembl:ENSAPLP00000008798.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000008798.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000008798.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000008798.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; U3INH5; -.
DR STRING; 8840.ENSAPLP00000008798; -.
DR Ensembl; ENSAPLT00000009483.2; ENSAPLP00000008798.2; ENSAPLG00000009032.2.
DR GeneTree; ENSGT00940000156804; -.
DR HOGENOM; CLU_014082_0_0_1; -.
DR OMA; LDDGCGD; -.
DR Proteomes; UP000016666; Chromosome Z.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR048827; C7_FIM2_N.
DR InterPro; IPR048825; C7_KAZAL.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR040729; Kazal_3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF2; COMPLEMENT COMPONENT C7; 1.
DR Pfam; PF21284; C7_FIM2_N; 1.
DR Pfam; PF21330; C7_KAZAL; 1.
DR Pfam; PF18434; Kazal_3; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 2.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..834
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019768277"
FT DOMAIN 122..443
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 556..615
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 616..677
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 91..109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 586..613
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 834 AA; 93387 MW; A831FC0604CD40B8 CRC64;
MKVLGIFVLL EVTGFFPIFS RPSYPVHCRW NSFGPWSECD GCTHKQIRRR TVAVYGQYGG
NPCSGDAFEI RSCIPTRGCP TEDGCGDRFR CFSGQCISRS LVCNGDQDCE EDGTDEDRCE
EKTTICDIDK TPPNAELTGT GFDAITGQTR GRVIHTKNFG GQCRKVFSND RREYYRLSES
ILAYTFQVKI QNDFSYEFFN SSWSYMKHVA RHETSDSGHY HKQRETKEHS QKSRQLMVIE
NSVEVAQFIN NRPDFLTLAE PFWKELANLP VVYDYNAYRR FIEYFGTHFL QSGSLGGYYK
LIFYMDTDKM KAEGLSTTDM YQCTSSGWNL LIVKKKKTEC SKLDELLRTS SGSSSNKIKG
DSYVEGGSPS AFAGLSYLEL DNPAGNSKKY SFWARSVTDY PKVIKQKLTP LYELVKEVPC
SSVKKHYLKQ AIEEYMAEND PCKCQPCQNG GEAAVDGTQC VCYCKPYTFG AACEMGTLVQ
DQPGVVDGHW SCWSSWSSCS GERKSRSRTC NNPSPSGGGK ACIGEHHESR PCEDEELQHL
RFIEPHCFDT SITPTEFCSP PPLLENGFIQ NAENSYPVGK SIVYACRHGY SLVGDPVAKC
GSNLQWQVGE RYCQETSCLL PVLEDGLQGD PWKPSYEIGE KITLSCIQGM RLEGAHSILC
EPSLKWSPDM KTIQCVKTES SVKTEVTEPK CQPWEKAQQS QCVCKMPYEC GPSLDVCATD
QRTKRNIPLT VCKMYALECT GRKYSLTSSD NCKTPQATEK SCGSCHSWER CDAESNSCVC
DEDASCEEGG IQICVEASGS AAHRTMTECE AGRLRCRGET VTLVSIRPCN VHSE
//
