ID U3IQP3_ANAPP Unreviewed; 1367 AA.
AC U3IQP3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Nuclear receptor coactivator 3 {ECO:0000313|Ensembl:ENSAPLP00000009566.2};
GN Name=NCOA3 {ECO:0000313|Ensembl:ENSAPLP00000009566.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000009566.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000009566.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000009566.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933}.
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DR Ensembl; ENSAPLT00000010262.2; ENSAPLP00000009566.2; ENSAPLG00000009790.2.
DR GeneTree; ENSGT00950000183021; -.
DR HOGENOM; CLU_001988_0_0_1; -.
DR Proteomes; UP000016666; Chromosome 21.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:InterPro.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18949; bHLH-PAS_NCoA3_SRC3; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF3; NUCLEAR RECEPTOR COACTIVATOR 3; 1.
DR Pfam; PF07469; DUF1518; 1.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 2.
DR SMART; SM01151; DUF1518; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 27..84
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 119..182
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1367 AA; 149543 MW; A3ED9FDC47903678 CRC64;
MSGLGENSLD SLANESRKRK PLPCDTPGAS LTCSGEKRRR EQESKYIEEL AELISANLSD
IDNFNVKPDK CAILKETVRQ IRQIKEQGKA VSNDDDVQKA DVSSTGQGVI DKDSLGPLLL
QALDGFLFVV NRDGNIVFVS ENVTQYLQYK QEDLVNTSVY GILHEEDRKD FLKNLPKSSV
NGVAWTNETP RQKSHTFNCR MMVKTSHDLL EDVGSHQDTR QRYETMQCFA LSQPRAMMEE
GEGKLVNIDT NSLRSSMRPG FEDTIRRCIQ RFLCHNDGQT WSNKRHYHEA YTQGHAETPL
YRFSLADGTI VTAQTKSKLF RNPVTNDRHG FVSTHFLQRE QNGYRTNPNT VGQNMRTPVA
GNTNSVGGLM NMSPSQSMPL QNRNYGMGDP NTVSQLSNSR YGGPGSMGPV NSGPGMQSSA
YQNNSYGLNI SSPPHGSPGL TSNQQNIMIS PRNRGSPKMS SHQFSPVTGM HSPMGSASNT
SNSTFSSSSL SALQAISEGV GTSLLSTLSS PGPKLDNSPN MSVAQQNKAS TQESKSPSGL
YCEQNQVESS LCQSNSRDLL SEKDSKEGSL ETPESQRGQS ESKGHKKLLQ LLTCSSDERG
HSTASNSPLE SNCKESSTNV TSPSGVSSST SGGVSSSSNM HGSLLQEKHR ILHKLLQNGN
SPAEVAKITA EATGKDTYHD SANIAPCGEG TVKQEQLSPK KKENNALLRY LLDKDDVKDP
LSKELKPKVE NVDNKMGQCS SSSIPTSSQE KDMKIKTEPT EEMSGDLDNL DAILGDLTSS
EFYNNAMSTN GNSFGTKQAL FQGNAPLSMR NPQSVQPTRP PFNRAMSLDS PVGSSAPVRN
VNAFSMLQKQ NMMGGSPRMI ENQENFGANL VSAPNRSVAM NQHQSGDWGL PNSKVNRLEP
TSSTSVMRPG PEFSASLPRP TAGSSMPGLP VRSNSIPGTR PMLQQQMIHM RSNEINMGLG
GNPYGQPAPS NQPGSWPDNM LSMEQASRSS QNRQLVRNSL DDLLCAAPNV EGQNEERALL
DQLHTLLSNT DVTSLEEIDR ALGIPDLVNQ GQALEAKQDS FQGQESAVMI DQKPSLYGQP
YQGQGAALPG GFSNIQGQQP SFNSVMNQMS QQSNFPLQSM HPRANVMRPR TNTPKQLRMQ
LQQRLQGQQF MNQTRQALEM KMENPGSNTS VMRPVMQPQV ASQQQGFLNA QMVAQRNREL
ISHHFRQQRM AMMMQQQQQP QAFSPPPNVT ASGSMDSGLT GPPMAQVPPQ QFSYPPNYGI
TQQPDPAFSR VSSPPNPMMS SRMGPSQNPM MQHPQAAAMY QSPEMKGWPS GSMTRSSSFP
QQQFSHQGNP ATYSMMHMNG SSGHLGQMNI NTMPMSGMPM GPDQKYC
//
