ID   U3IS72_ANAPP            Unreviewed;       912 AA.
AC   U3IS72;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 2.
DT   24-JAN-2024, entry version 57.
DE   SubName: Full=Potassium voltage-gated channel subfamily Q member 5 {ECO:0000313|Ensembl:ENSAPLP00000010095.2};
GN   Name=KCNQ5 {ECO:0000313|Ensembl:ENSAPLP00000010095.2};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000010095.2, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000010095.2, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000010095.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; U3IS72; -.
DR   STRING; 8840.ENSAPLP00000010095; -.
DR   Ensembl; ENSAPLT00000010802.2; ENSAPLP00000010095.2; ENSAPLG00000010359.2.
DR   GeneTree; ENSGT00940000155933; -.
DR   HOGENOM; CLU_011722_10_2_1; -.
DR   OMA; HKQKLFR; -.
DR   Proteomes; UP000016666; Chromosome 3.
DR   GO; GO:0030118; C:clathrin coat; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 6.10.140.1910; -; 2.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR   PANTHER; PTHR47735:SF8; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 5; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01461; KCNQ2CHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        114..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        142..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        256..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        313..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          114..343
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          434..621
FT                   /note="Potassium channel voltage dependent KCNQ C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03520"
FT   REGION          391..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          699..728
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..409
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..452
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   912 AA;  100162 MW;  20BB3887B0399BF4 CRC64;
     MPRNHGGGEE GGSAGLWVKS GAAAGMKDVE SGRGRALASA AARGDGLLLL GTAGGAAAPA
     GLREGRRGKH GARMSLLGKP LSYSSGPSCR RNAKYRRLQN YLYNVLERPR GWAFVYHAFV
     FLLVFGCLIL SVFSTIPEHT KLASGCLFIL EFVMIVVFGL EFIIRIWSAG CCCRYRGWQG
     RLRFARKPFC VIDIIVLIAS IAVVSAKTQG NIFATSALRS LRFLQILRMV RMDRRGGTWK
     LLGSVVYAHS KELITAWYIG FLVLIFSSFL VYLVEKDANN QFSTYADALW WGTITLTTIG
     YGDKTPLTWL GRLLSAGFAL LGISFFALPA GILGSGFALK VQEQHRQKHF EKRRNPAASL
     IQCVWRSYAA DEKSVSIATW KPHLKALHTC SPTKKEQGEA SSSQKLSFKE RVRMASPRGQ
     SIKNRQSSVG DRRSPSADIA TEGSPTKVQK SWSFNDRTRF RPSLRLKSSQ PKPVVDADTS
     LGTDDVYDDK GCQCDVSVED LTPALKTVIR AIRIMKFHVA KRKFKETLRP YDVKDVIEQY
     SAGHLDMLCR IKSLQSRVDQ ILGKGQITAD KRSREKNTAE NETTDDLSML GRVVKVEKQV
     QSIESKLDCL LDIYQQVLRK GSASALTLAS FQMPAFECEQ TSDYQSPSDS KDLSNSAQIS
     GCVSRSASAN LPRGLQLILT PNEFSTQAYY AFSPAMHSQA TQVPNDGPTT ANNTSNQINQ
     ATKPATPTTL QIPPFSSMKH INRPEPVHII PVTTQENISD VTACLVASKD NGQVAQPSAT
     KDLAWRKGLD TEGEPLLSVK PVVQMDLGKS LSVQNLIQST EELNVQITGS DSSGSRGSQD
     VYSKWRESKL FITDEELETE AGTETTEAIS RPLVETTLST DSLRTGISRS SQNICKPGDG
     TEALSLLHVK LK
//