ID U3IUH4_ANAPP Unreviewed; 852 AA.
AC U3IUH4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=L3MBTL histone methyl-lysine binding protein 3 {ECO:0000313|Ensembl:ENSAPLP00000010897.2};
GN Name=L3MBTL3 {ECO:0000313|Ensembl:ENSAPLP00000010897.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000010897.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000010897.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000010897.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; U3IUH4; -.
DR Ensembl; ENSAPLT00000011615.2; ENSAPLP00000010897.2; ENSAPLG00000011121.2.
DR GeneTree; ENSGT00940000159800; -.
DR HOGENOM; CLU_004064_0_1_1; -.
DR Proteomes; UP000016666; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20132; MBT_L3MBTL3_rpt1; 1.
DR CDD; cd20135; MBT_L3MBTL3_rpt2; 1.
DR CDD; cd20138; MBT_L3MBTL3_rpt3; 1.
DR CDD; cd09582; SAM_Scm-like-3MBT3_4; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 3.30.60.160; -; 1.
DR Gene3D; 4.10.320.30; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247:SF72; LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF01530; zf-C2HC; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF103637; CCHHC domain; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51802; ZF_CCHHC; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT REPEAT 303..403
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 411..510
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 519..614
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 780..844
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 95471 MW; 675F1FAADC26BEAB CRC64;
MPHLRRSPCS GPGFGAGFGA GGRRRPPRRV PRAAAAPEPR PREEERAAAA AVSPFPSPGS
AGACSLVPAA LDHICQDCSR AGERERENLG GACIMNESAA SGNGQEFDVF SAMDWKDGIG
TLPGSDLKFR VNEFGALEVI TDETEMENVK KATATTTWMV PTAQEAFSEK TGIPTKLKET
AKMDGLVFCE NCYRYGTIEE FVPEGKFCSQ KCAQQVKNKE PKEEKPNVEC NGEDDSKGIR
KRKAKLPLKE ESRDNGEKKE NPSETEDKPE GRILRVSQRA RRKRKGEITV LKQTVHSKGK
QAWCWASYLE EEKAVAVPTK LFKEYQSFPY NKNGFKVGMK LEGVDPEHQS IYCVLTVAEV
CGYRIRLHFD GYPDCYDFWV NADSSDIHPV GWCEKTGHKL HPPKGYKEEE FSWPSYLKAC
KAQAAPKSLF ENQNTTVIPS GFRVGMKLEA VDKKNPTFIC VATVTDMVDN RFLVHFDNWD
ESYDYWCEAA SPHIHPVGWC KEHKRTLITP PDYPHAKHFS WEKYLEETSS LPAPARAFKV
KPSHGFQKNM KLEVVDKRNP VFIRVATIVD TDDYRIKVHF DGWDSIYDYW TDVDSPDIHP
AGWCTKTGHP LQPPLSPLEL VEALEHGGCP TAGCKGVGHI KRARHIGHHS AVSCPYSEMN
LNKESLLPDR LSGEMPATNP VPRNRRVEAR ERSPSPVING VLQTKDSIKN KECEEEEIEN
KLLISNEIKD TEEPNTQRLL SQPVVVSSKL QIPGLPLRWE QHSKLLPSVA GIPASKVSKW
STDEVSEFIR SLPGCEEHGK VFKDEQIDGE AFLLMTQSDI VKIMSIKLGP ALKIFNSILM
FKAAEKNSHN EL
//
