ID U3IUW5_ANAPP Unreviewed; 504 AA.
AC U3IUW5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DnaJ homolog subfamily C member 3 {ECO:0000256|ARBA:ARBA00039409};
GN Name=DNAJC3 {ECO:0000313|Ensembl:ENSAPLP00000011038.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000011038.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000011038.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000011038.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; U3IUW5; -.
DR STRING; 8840.ENSAPLP00000011038; -.
DR Ensembl; ENSAPLT00000011759.2; ENSAPLP00000011038.2; ENSAPLG00000011218.2.
DR GeneTree; ENSGT00940000159806; -.
DR HOGENOM; CLU_015935_0_0_1; -.
DR OMA; PFAHFQH; -.
DR Proteomes; UP000016666; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:Ensembl.
DR GO; GO:0051787; F:misfolded protein binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0070417; P:cellular response to cold; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:1903912; P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation; IEA:Ensembl.
DR GO; GO:0036494; P:positive regulation of translation initiation in response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:Ensembl.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44140:SF3; DNAJ HOMOLOG SUBFAMILY C MEMBER 3; 1.
DR PANTHER; PTHR44140; LD25575P; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF14559; TPR_19; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50005; TPR; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..504
FT /note="DnaJ homolog subfamily C member 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019739774"
FT REPEAT 71..104
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 105..138
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 222..255
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 394..462
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
SQ SEQUENCE 504 AA; 57489 MW; 5BE6DB1E6713EABE CRC64;
MVCAAASAGR LGPALPFLIV LLDLRHHGAE CGINADVEKQ LEMGKKLLAA GQLADALSHF
HAAIEGDSDN YIAYYRRATV YLAMGKSKAA IRDLSKVVEL KQDFTSARLQ RGQLLLKQGK
FDEAEDDFKN VLKSNPSNNE EKDAQTQLTK SDELQRLHSQ ALSAYQQEDY EAAISLLDEI
LAVCVWDAEL RELRAECYIK EGEPSKAISD LKAAAKLKND NTEAFYKISR IYYQLGDHEL
SLSEVRECLK LDQDHKQCFS LYKQVKKLNK QIESAEEFIR EGRYEDAINK YDSVMKTERD
VPIYATRAKE RICHCLSKNQ QATEAIKVCT EVLQLEPTNV NALKDRAEAY LLEDLYEEAI
KDYETAQANS ENDQQIREGL ERAQRMLKQS QKRDYYKILG VKRNARKQEI IKAYRKLASQ
WHPDNFQSEE EKKKAEKKFI DIAAAKEVLT DPEMRRKFDA GEDPLDAESQ QGGGNPFHRN
WNTWQGFNPF GSGGGPFTFK FHFS
//
