ID U3IX06_ANAPP Unreviewed; 604 AA.
AC U3IX06;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=Kelch-like protein 15 {ECO:0000256|ARBA:ARBA00019835};
GN Name=KLHL15 {ECO:0000313|Ensembl:ENSAPLP00000011782.1};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000011782.1, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000011782.1, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000011782.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; U3IX06; -.
DR STRING; 8840.ENSAPLP00000011782; -.
DR Ensembl; ENSAPLT00000012513.2; ENSAPLP00000011782.1; ENSAPLG00000012028.2.
DR GeneTree; ENSGT00940000159116; -.
DR HOGENOM; CLU_004253_16_1_1; -.
DR OMA; ADQWTIL; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000016666; Chromosome 1.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd18454; BACK_KLHL15; 1.
DR CDD; cd18244; BTB_POZ_KLHL15; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR030597; BTB_POZ_KLHL15.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR047030; KLHL15_BACK.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF12; KELCH-LIKE PROTEIN 15; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 5.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 31..98
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 604 AA; 69714 MW; 5216D03A9F19A3DE CRC64;
MAGDVEGFSS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF
TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC
CSFLLAKICL ENCAEIMRLL DDFGVNIEGV REKLDSFLLE NFVPLMSRPD FLSYLSFEKL
MSYLDNDHLS RFPEIELYEA VQAWLRHDRR RWRHTDTIIQ NIRFCLMTPS SVFEKVKTSE
FYRYSRQLRH EVDQAMNYFH SVHQQPLMEM KSNKIRSAKP QTAVFRGMIG HSMVNSKILL
LHKPRVWWEL EGPQVPLRPD CLAIVNNFVF LLGGEELGPD GEFHASSKVF RYDPRQNTWL
RMADMSVPRS EFAVGVIGRY VYAVAGRTRD ETFYSTERYD ITEDKWEFVD PYPVNKYGHE
GTVLGNKLYI TGGITSSSTS KQVCVFDPSK EGTVEQRTRR TQVVTNCWEN KCKMNYARCF
HKMISYNGKL YVFGGVCVIL RASFESQGCP STEVYDPDTD QWTILASMPI GRSGHGVAVL
DKQIMVLGGL CYNGHYSDSI LTFDPEENKW KEDEYPRMPC KLDGLQVCSL HFPEYVLEHV
RRCS
//
