ID U3IY40_ANAPP Unreviewed; 1327 AA.
AC U3IY40;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=ATP binding cassette subfamily C member 4 {ECO:0000313|Ensembl:ENSAPLP00000012166.2};
GN Name=ABCC4 {ECO:0000313|Ensembl:ENSAPLP00000012166.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000012166.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000012166.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000012166.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSAPLT00000012900.2; ENSAPLP00000012166.2; ENSAPLG00000012227.2.
DR GeneTree; ENSGT00940000153931; -.
DR HOGENOM; CLU_000604_27_3_1; -.
DR OMA; ACAQWFH; -.
DR Proteomes; UP000016666; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18593; ABC_6TM_MRP4_D1_like; 1.
DR CDD; cd18601; ABC_6TM_MRP4_D2_like; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR030240; ABCC4_TMD1.
DR InterPro; IPR047083; ABCC4_TMD2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF357; ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 4; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 80..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 769..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 950..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..374
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 408..631
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 715..1007
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1043..1276
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1327 AA; 149645 MW; F4ED820D664C9D1C CRC64;
MEAVPREEKP NPLRDANLCS RLFFWWLNPL FIIGHKRKLE EDDMYKVLPE DSSEKLGEEL
QWYWDKEVQK AKKRGKTPHL TKAIILCYWK SYLVFGIFTM IEETLKIVQP ILLGKIINYF
ENYDEAALKF AYCYAGALSV CTLILAIMHH LYFYHVQRAG MKLRVAMCHM IYRKALRLSN
VAMAKTTTGQ IVNLLSNDVN KFDQVTIFLH FLWAGPIQAV AVTVLLWMEI GPSCLAGMAV
LIILLPVQTC IGRLFSSLRS KTAAFTDVRI RTMNEVISGM KIIKMYAWEK SFAELVSGLR
RKEIAMVMKS SYLRGLNLAS FFVASKITVF MTFMAYVLLG NVISASRVFV AVSLYGAVRL
TVTLFFPAAV ERVSEAVVSI RRIKNFLILD EVSHFKPQLH GSNDNVILHV QDLTCYWDKS
LETPALQQLS FTVRRGELLA VIGPVGAGKS SLLSAVLGEL PKDKGLINVT GRIAYVSQQP
WVFSGTVRSN ILFDKEYEKE KYEKVLKVCA LKKDLELLAD GDLTVIGDRG ATLSGGQKAR
VNLARAVYQD ADIYLLDDPL SAVDAEVGRH LFEKCICQAL HQKISVLVTH QLQYLRAATQ
ILILKDGKMV GKGTYSEFLR SGIDFASLLK KDEEAEQPSV PGTPNLKASR SRTFSESSVW
SQDSSVHSMK DGAVEPPPAE NALAAVPEES RSEGKINFKV YRKYFTAGAN YFVIFILILF
NILAQVAYVL QDWWLSYWAN HQEKLNVTTN GNNGANETEH LDLTFYLGIY AGLTVAAILF
GIIRSLLVFQ VLVNSGQTLH NKMFQAILKA PVLFFDRNPI GRILNRFSKD IGHLDDLLPL
TFLDFVQTLL QIFGVVAVAV AVIPWILIPL IPLFILFIFL RRYFLDTSRD IKRLESTTRS
PVFSHLSSSL QGLWTIRALK AEERFQKLFD AHQDLHSEAW FLFLTTSRWF AVRLDAICAI
FVVVVAFGSL LLAKTLNAGQ VGLALSYAIT LMGTFQWGVR QSAEVENLMI SVERVMEYTD
LEREAPWETN KHPPPEWPSQ GMIAFENVNF TYSLDGPLVL RHLSVVIKPK EKVGIVGRTG
AGKSSLIAAL FRLAEPEGRI WIDKYLTSEL GLHDLRKKIS IIPQEPVLFT GTMRKNLDPF
NEYTDEDLWN ALEEVQLKEV VEDLPNKMET QLAESGSNFS VGQRQLVCLA RAVLKKNRIL
IIDEATANVD PRTDEFIQKT IREKFAQCTV LTIAHRLNTI IDSDRIMVLE AGRLKEYGEP
YILLQEKDGL FYKMVQQVGK TEAASLFETA KRVYFSKNYP EVVQNGQLAA DSSLDPSSGL
CITETAL
//
