ID U3J021_ANAPP Unreviewed; 993 AA.
AC U3J021;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Ras and Rab interactor 2 {ECO:0000313|Ensembl:ENSAPLP00000012848.2};
GN Name=RIN2 {ECO:0000313|Ensembl:ENSAPLP00000012848.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000012848.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000012848.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000012848.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC {ECO:0000256|ARBA:ARBA00006919}.
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DR AlphaFoldDB; U3J021; -.
DR Ensembl; ENSAPLT00000013593.2; ENSAPLP00000012848.2; ENSAPLG00000014865.2.
DR GeneTree; ENSGT00940000154866; -.
DR HOGENOM; CLU_007948_5_2_1; -.
DR Proteomes; UP000016666; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd16131; RA_Rin2; 1.
DR CDD; cd10394; SH2_RIN2; 1.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR035868; RIN2_SH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF42; SODIUM_POTASSIUM_CALCIUM EXCHANGER 3; 1.
DR Pfam; PF01699; Na_Ca_ex; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..993
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019776132"
FT TRANSMEM 72..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 577..670
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 720..859
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT DOMAIN 889..980
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 273..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..329
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 993 AA; 112087 MW; DA5ECCAA84E5C063 CRC64;
MGFDYPFHWF DTTSLILCVC DLALTALQVW PSHPSSYSTS SLRKPVHLIP AISSPCPSVH
GDSFHRVTGL TMALAVDMAV VLVRAWLTSF LCLFSQVVAL SSWSLLRDSI YYTLSVVALI
VFIYDEKVSW WESLVLVLMY AIYIVIMKYN STIHHCFERK TKNAANMVNG LANNTEMDDN
SNCDATVVLL KKGNFHRKAS VIMVDELLSA YPHQLSFSEA GLRIMITSHF PPKTRLSMAS
RMLINERQRL INSRTYTNGE SEVAIKIPIK HVVENGTGPS NSAERSMNST RREEDTAEAG
TETENENEDN ENNENDEEED EDDDNDDHEG PYTPFDLPTG KTEVLKWLFT WPLSFVLYFT
VPNCNKPHLE KWFMVTFASS TLWIAAFSYM MVWMVTIIGY TLGIPDVIMG ITFLAAGTSV
PDCMASLIVA RQGMGDMAVS NSIGSNVFDI LIGLGLPWAL QTLAVNYGSY DFKTFSGVFP
GTMSSLTMKA HCLDKRGSFF KLIDTIASEI GELKHEMVQT DLTVEDESAD LQSLVKDMGN
VSPEKKDVKG CPRDSGYDSL SNKLSILDKL LHTHPVWLQL GLNDAEAMEI LRAQPAGIFL
VRKSARLQKK VISLRLPSDC GSCLKEFAIK ESTYTFSLEG SGISFADLFR LIAFYCISRD
VLPFTLKLPH AIAAAKTEIE LEEIAQLGLN VVLEKAMHKC ILKPLKGHIE AMLKEFHTAD
GSWKQLKENL QLVRQRNPQE LGVFVPTPDF VDVEKIKVKF MTMQKMYSPE KKVMLLLRVC
KLIYTVMENN SGRLYGADDF LPVLTYVLAQ CDMLELDTEI EYMMELLDPS LLHGEGGYYL
TSAYGALSLI KNFQEEQAAR LLSSEARDTL RQWHKRRTTN RTIPSVDDFQ NYLRVAFQEV
NSGCTGKTLL VRPYITTEDV CQLCAEKFKV DNPKEYSLFL FVDDTWQQLT EDTYPQKIKA
ELHSRPQPQV FHFVYKRINS DPYGAIFQNN SAS
//
