ID U3J0V2_ANAPP Unreviewed; 509 AA.
AC U3J0V2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=DNA-dependent metalloprotease SPRTN {ECO:0000256|ARBA:ARBA00023885};
DE AltName: Full=Protein with SprT-like domain at the N terminus {ECO:0000256|ARBA:ARBA00030396};
GN Name=SPRTN {ECO:0000313|Ensembl:ENSAPLP00000013129.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000013129.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000013129.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000013129.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Spartan family.
CC {ECO:0000256|ARBA:ARBA00010724}.
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DR AlphaFoldDB; U3J0V2; -.
DR STRING; 8840.ENSAPLP00000013129; -.
DR Ensembl; ENSAPLT00000013877.2; ENSAPLP00000013129.2; ENSAPLG00000013330.2.
DR GeneTree; ENSGT00390000003585; -.
DR HOGENOM; CLU_019426_2_0_1; -.
DR OMA; EEYRRHW; -.
DR Proteomes; UP000016666; Chromosome 3.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:Ensembl.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0016540; P:protein autoprocessing; IEA:Ensembl.
DR GO; GO:0106300; P:protein-DNA covalent cross-linking repair; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR GO; GO:0019985; P:translesion synthesis; IEA:Ensembl.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR044245; Spartan.
DR InterPro; IPR006640; SprT-like_domain.
DR PANTHER; PTHR21220:SF0; DNA-DEPENDENT METALLOPROTEASE SPRTN; 1.
DR PANTHER; PTHR21220; UNCHARACTERIZED; 1.
DR Pfam; PF10263; SprT-like; 1.
DR SMART; SM00731; SprT; 1.
DR SMART; SM00734; ZnF_Rad18; 1.
DR PROSITE; PS51908; ZF_UBZ4; 1.
PE 3: Inferred from homology;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01256}.
FT DOMAIN 485..509
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 509 AA; 57176 MW; D22632B77549509A CRC64;
MWSASYSSSS PLYTRNLPGL SGSRSRQPST FSRRVVSVRC RPSSPPPAAS LPDSGRNGSE
GARAGSSRSA WRSRACVTAS MMPFCSVRMW LSWYISLSRC AGVCRYEGKG GMCSIRLSEP
LLKLRPRKDL VETLLHEMIH ALLFVTNNDR DRESHGPEFC KHMRRINRLT GANVTIYHNF
HDEVDLYRQH WWRCNGPCQN RKPYFGYVKR SMNRAPSARD FWWAEHQEKC GGTFIKVKEP
ENFSKKSKEK NEPAEPPNSK STNKDKKHVD AKKDLVPFSG NGYRLGGREG GLSEKNINFI
SSIKNSEKSD WQHRPAGSTI PIPKNEIKFE KSPRNGISFP FCTDGTSKKV NLASKRDFPK
LSVADTKAYK NVGGSPVKIS RVVEEQSKQG SAKGKRALPG YNNRPPKQTC FEQTTTGQVA
SEKKGLENRV QQWPKKEDKT AFENYFIKKE STDTTLSINT PMKTKAESTV SSSASSSATE
RREKTVSCPV CQAEVLEPKI NEHLDSCLA
//
