ID U3J2R5_ANAPP Unreviewed; 322 AA.
AC U3J2R5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Lumican {ECO:0000256|ARBA:ARBA00013370};
GN Name=LUM {ECO:0000313|Ensembl:ENSAPLP00000013792.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000013792.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000013792.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000013792.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Binds to laminin. {ECO:0000256|ARBA:ARBA00011719}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class II subfamily. {ECO:0000256|ARBA:ARBA00005818}.
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DR AlphaFoldDB; U3J2R5; -.
DR Ensembl; ENSAPLT00000014557.2; ENSAPLP00000013792.2; ENSAPLG00000013979.2.
DR GeneTree; ENSGT00940000158177; -.
DR HOGENOM; CLU_000288_186_4_1; -.
DR OMA; DCPINFP; -.
DR Proteomes; UP000016666; Chromosome 1.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF6; LUMICAN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01462; LRRNT; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022974};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..322
FT /note="Lumican"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019740931"
FT DOMAIN 39..73
FT /note="LRRNT"
FT /evidence="ECO:0000259|SMART:SM00013"
SQ SEQUENCE 322 AA; 36325 MW; D53F25F385FCFBF3 CRC64;
MTLNSLHIFL VLISGIFCQY DYGPADDYGY DPFGPSSAVC APECNCPLSY PTAMYCDNLK
LKTIPIVPSG IKYLYLRNNM IEGIEENTFD NVTDLQWLIL DHNHLENSKI KGRVFSKLKH
LKKLHINYNN LTEAVGPLPK TLDDLQLSHN KITKVNPSAL EGLANLTVIH LQNNQLKADS
ISGAFKGLNS LLYLDLSFNR LTKLPTGLPH SLLMLYFDNN QISNIPDEYF QGFKTLQYLR
LSHNKLTDSG IPGNVFNITS LVELDLSFNQ LKSIPTVSEN LENFYLQVNK INNISYLNIV
KTTEFLLGTD TFSEKITVQS SH
//
