ID U3J2Y5_ANAPP Unreviewed; 635 AA.
AC U3J2Y5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Solute carrier family 7 member 3 {ECO:0000313|Ensembl:ENSAPLP00000013862.2};
GN Name=SLC7A3 {ECO:0000313|Ensembl:ENSAPLP00000013862.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000013862.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000013862.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000013862.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine(in) = L-arginine(out); Xref=Rhea:RHEA:32143,
CC ChEBI:CHEBI:32682; Evidence={ECO:0000256|ARBA:ARBA00034423};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine(in) = L-lysine(out); Xref=Rhea:RHEA:70935,
CC ChEBI:CHEBI:32551; Evidence={ECO:0000256|ARBA:ARBA00034422};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-ornithine(in) = L-ornithine(out); Xref=Rhea:RHEA:71199,
CC ChEBI:CHEBI:46911; Evidence={ECO:0000256|ARBA:ARBA00034450};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
CC {ECO:0000256|ARBA:ARBA00008572}.
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DR AlphaFoldDB; U3J2Y5; -.
DR STRING; 8840.ENSAPLP00000013862; -.
DR Ensembl; ENSAPLT00000014629.2; ENSAPLP00000013862.2; ENSAPLG00000014008.2.
DR GeneTree; ENSGT00940000154651; -.
DR HOGENOM; CLU_007946_15_7_1; -.
DR OMA; TLGWPHL; -.
DR Proteomes; UP000016666; Chromosome 10.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0061459; F:L-arginine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015189; F:L-lysine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0000064; F:L-ornithine transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0097638; P:L-arginine import across plasma membrane; IEA:Ensembl.
DR GO; GO:0097639; P:L-lysine import across plasma membrane; IEA:Ensembl.
DR GO; GO:0097640; P:L-ornithine import across plasma membrane; IEA:Ensembl.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR004755; Cat_AA_permease.
DR InterPro; IPR029485; CAT_C.
DR NCBIfam; TIGR00906; 2A0303; 1.
DR PANTHER; PTHR43243:SF20; CATIONIC AMINO ACID TRANSPORTER 3; 1.
DR PANTHER; PTHR43243; INNER MEMBRANE TRANSPORTER YGJI-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR Pfam; PF13906; AA_permease_C; 1.
DR PIRSF; PIRSF006060; AA_transporter; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 410..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 555..605
FT /note="Cationic amino acid transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13906"
FT REGION 614..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 68439 MW; 8AC0C8B19AFB26BA CRC64;
MFGGKMSSVG KKLIRRRVVD LSSEETRFAR CLSTLDLIAL GVGSTLGAGV YVLAGEVAKD
RAGPSIVLCF LVAALSSVLA GLCYAEFGAR VPKTGSAYLY SYVTVGEIWA FTTGWNLILS
YVIGTASVAR AWSAAFDNII GNHISTFFMN KTTVHVPGVL AERPDFFALI LIALLTALLA
FGVSESALVN KIFTAVNLLV LGFVIIAGFI KGNIKNWQLT EEDYHNLVSP DVSNETRIKE
FGSGGFVPFK LEGILTGAAT CFYAFVGFDC IATTGEEARN PQRSIPIGII VSLLICFVAY
FGVSAALTLM VPYFLLDKGS PLPEAFKAVG WEPARYAVAV GSLCALSTSL LGSMFPMPRV
IYAMAEDGLL FKFLSSINSR TKTPLSATIT SGLLAAVMAF LLELKDLVDL MSIGTLLAYS
LVAVCVLILR YQSGQLNSPK AVEMLELNGN EEERVVMNPS ITAMGTKEIE KPSLMTLFNP
PSDTPTALSG RIVYTCVCVI ATLITIICVV LTLKVNALKE ANVGWISAVV LLVVVLLVPT
IIIWRQPQSN ARLNFKVPLL PLLPLVSIFV NILLMVQLSA GTWARFAIWM AVGFMIYFGY
GIRNSVEGKN AEPRAVAEKP LHHPEPDLNP RATAV
//
