ID   U3J342_ANAPP            Unreviewed;       814 AA.
AC   U3J342;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=DNA helicase B {ECO:0000313|Ensembl:ENSAPLP00000013919.2};
GN   Name=HELB {ECO:0000313|Ensembl:ENSAPLP00000013919.2};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000013919.2, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000013919.2, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000013919.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; U3J342; -.
DR   STRING; 8840.ENSAPLP00000013919; -.
DR   Ensembl; ENSAPLT00000014687.2; ENSAPLP00000013919.2; ENSAPLG00000014085.2.
DR   GeneTree; ENSGT00390000006913; -.
DR   HOGENOM; CLU_010264_0_0_1; -.
DR   OMA; CTKNAYL; -.
DR   Proteomes; UP000016666; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005662; C:DNA replication factor A complex; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR   GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0017116; F:single-stranded DNA helicase activity; IEA:Ensembl.
DR   GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:Ensembl.
DR   GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:1903775; P:regulation of DNA double-strand break processing; IEA:Ensembl.
DR   CDD; cd17933; DEXSc_RecD-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43788:SF21; DNA HELICASE B; 1.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF13604; AAA_30; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          410..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..431
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   814 AA;  92671 MW;  7DA0924E103EC886 CRC64;
     MAAAGRGPAA ELRGVLLPPR RDPRGSEDGD SEEEEEEEAE EELLLAEAAL LEDAGREMAA
     ALPPLVIQDN SKEEHEAVGR FPLVGPWWKV NVKVKKVGSK YFVQGYPSYF LRTDIEENNR
     QVFSLFLKEC KVPDYFREQF FTWLPPECAL SFGNLEEKLK QFQYSHPPTG KKQGDTKDFD
     ILHYVLKSGR SVGLPKWNCL CYRLLVALTF PMILEFLPIL LPRHFCCLLN MVNEMLTKLD
     AILKNEPWKL GFNRKITYRE LKLSYCEATW EAFRQCERLL RQIPDLQKNA LILYDKLKKR
     CREMGHTYED QDELTNFVSK DMSIEHAWQS LEFLKDEKIV IREKKLVFLP HLYKSERDIA
     MYIGRLLSNC SWQLNVDARK ILNTFETSGE TADDEMNAVS AHEMEHLKED NPGNHNCENP
     QMESTAGTQS KGEVDIDQVT AIEKICSNPV TIISGKGGCG KSTVVSCLFS HLKQVEKEVE
     AASKDFEGDL DASEEWGTFD HHSESENTGT KNCLNILLTA PTGRAASLLS EKTRLPAYTL
     HQIIYSFKSW RQTGQEFPWK FSTVTVLIVD EGSLVSVHVL SLVLKLLYEH AELAKLIILG
     DTRQLPSIDP GNVLLDIFES LKPRGFSVEL RTNHRAESQL IVDNATRISQ RKFPEFDEVL
     EVSGWNKALT MPRPEKKFIF IALPSGGGSD SKCVHSVCDL DLPFCKAKTV WLELTFLGDF
     NCDLINELCC QHYSKHLTRD HKRRLLFQID DKISCTRNTY LKDLLPGHGF GKEPDQKEDH
     KCRNGETTLS SATAEDGKRL CNGDIFFITD VSCC
//