ID U3J352_ANAPP Unreviewed; 498 AA.
AC U3J352;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Integrator complex subunit 14 {ECO:0000256|ARBA:ARBA00016816};
DE AltName: Full=von Willebrand factor A domain-containing protein 9 {ECO:0000256|ARBA:ARBA00029992};
GN Name=INTS14 {ECO:0000313|Ensembl:ENSAPLP00000013929.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000013929.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000013929.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000013929.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Probable component of the Integrator (INT) complex, a complex
CC involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and
CC in their 3'-box-dependent processing. {ECO:0000256|ARBA:ARBA00003473}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the INTS14 family.
CC {ECO:0000256|ARBA:ARBA00007451}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; U3J352; -.
DR Ensembl; ENSAPLT00000014696.2; ENSAPLP00000013929.2; ENSAPLG00000014064.2.
DR GeneTree; ENSGT00390000009486; -.
DR HOGENOM; CLU_041485_0_0_1; -.
DR OMA; QSSVVWI; -.
DR Proteomes; UP000016666; Chromosome 11.
DR GO; GO:0032039; C:integrator complex; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR039841; INTS14.
DR InterPro; IPR045814; IntS14_b-barrel.
DR InterPro; IPR046471; IntS14_C.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13532:SF3; INTEGRATOR COMPLEX SUBUNIT 14; 1.
DR PANTHER; PTHR13532; UNCHARACTERIZED; 1.
DR Pfam; PF19435; IntS14_b-barrel; 1.
DR Pfam; PF20504; IntS14_C; 1.
DR Pfam; PF13519; VWA_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666}.
FT DOMAIN 3..117
FT /note="VWFA"
FT /evidence="ECO:0000259|Pfam:PF13519"
FT DOMAIN 209..356
FT /note="Integrator complex subunit 14 beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF19435"
FT DOMAIN 404..488
FT /note="Integrator complex subunit 14 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF20504"
FT REGION 373..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 55476 MW; 7148E68E81B25346 CRC64;
MPTVVVMDVS LSMTRPVSVE GSEEYQRKHL AVHGLTMLFE HMATNYKLEF TALVVFSSLW
ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALLGVCNIVQ QEWGAAIPCQ VVLVTDGCLG
IGRGSLRHSL ATHNQRSESN RFPLPFPFPS KLYVMCMANL EELQSTDSLD CLERLIDLNN
GEGQIFTIDG PLCLKNVQSM FGKLIDLAYT PFHAVLKCGH LTSDVQVFPR PEPFIIDEEI
DPIPKAINTD LEIVGFVDIA DISSPPVLSR HLVLPIALNR EGDEVGPGIT DDTEDENSAN
QIAGKIPNFC VLLHGSLKVE GMVAVVQLGP EWYGMLYSQA DSKKKSNLMM SLFEPGPEPL
PWLGKMAQLG PISDAKENPY GDDDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL
RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVADML ERECTLLPDT AHPDAAFQLT
HAAQQLKVCL HYQSGKHF
//
