ID U3J3A5_ANAPP Unreviewed; 1901 AA.
AC U3J3A5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 05-JUN-2019, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=TRPM6 {ECO:0000313|Ensembl:ENSAPLP00000013982.2};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000013982.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000013982.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000013982.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the protein kinase
CC superfamily. Alpha-type protein kinase family. ALPK subfamily.
CC {ECO:0000256|ARBA:ARBA00025760}.
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DR STRING; 8840.ENSAPLP00000013982; -.
DR Ensembl; ENSAPLT00000014750.2; ENSAPLP00000013982.2; ENSAPLG00000014165.2.
DR GeneTree; ENSGT00940000158164; -.
DR HOGENOM; CLU_001390_2_0_1; -.
DR Proteomes; UP000016666; Chromosome Z.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR Gene3D; 3.20.200.10; MHCK/EF2 kinase; 1.
DR Gene3D; 1.20.5.1010; TRPM, tetramerisation domain; 1.
DR InterPro; IPR004166; a-kinase_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR041491; TRPM_SLOG.
DR InterPro; IPR032415; TRPM_tetra.
DR InterPro; IPR037162; TRPM_tetra_sf.
DR PANTHER; PTHR13800:SF15; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 6; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF02816; Alpha_kinase; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
DR Pfam; PF16519; TRPM_tetra; 1.
DR SMART; SM00811; Alpha_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51158; ALPHA_KINASE; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 679..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 910..930
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 983..1005
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1634..1864
FT /note="Alpha-type protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS51158"
SQ SEQUENCE 1901 AA; 218336 MW; 1A3DEEAF060EB4A6 CRC64;
SWPVYQPALQ RDEEWSVQKH TKMSPTDAFG TIKFQDGDHT YHAKYIRLSY DSNLDQLLHL
MVKEWQMELP KLVISVHGGI QNFQLPSKIK QVFSKGLVKA AETTGAWIIT EGINSGVSRH
VGDALKGRTS PYLRKICAVG IPPWGIIENQ RDLIGKDVVC LYQTLGNPLS KLSTLNSMHS
HFLMADDGTV GKYGNEMMLR RNLEKYLSLQ KIHARMGQGV PIVGLVVEGG PNVILMVWEY
VRTSPPVPVV VYDGTGRAAD ILAFTHKHTG DTGELRPQVK EEVLVMIQNM FSLGQKQSSH
LFHILMECME HRESITILDV ESEEQQDIDL AILTALLKGT NMSASDQLDL ALAWNQLDIA
KKHILVYGQH WKVGALEQAM QDALVMDRVD FVKLLIEHGV NMHHFLTISR LEELYNTKQG
PSNLLLHHLV RDVKQSTLPS DYRISLIDIG LVVEYLLGGA YRSSYTRKHF RILYNDLYRK
HKNNQMGSRM ASAENTLHSQ FFRTAQPYKC KERSTGFHKS KKKSKEDGNF AENYESPGFT
YPYNDLLVWA VLMKRQKMAM FFWQHGEEAM VKAVVACKLY KAMAHEAKQS NMVDDTSEEL
KKYSKEFGQL ALDVLEKAFK QNEQMAMKLL TYELKNWSNS TCLKLAVSVG MRPFVSHTCT
QMLLTDMWMG RLKMRKNSWF KVIISILLPP TILMLEFKTK AEMSHVPQSQ DFHQFTWYHG
DQSPPSTKDV LSLKDCDVEK VTQKSDESQV DGGQRNLPRT RKIYEFYNAP IVKFWFHTMA
YMAFLMLFTY TVLVKMEPRP SVQEWLVIIY IFSTAIEKVR EVFISEPGKF SQKVKVWINE
YWNFTDSIAI ILFMIGFGLR WSEPPVQTAG RLLYCLDIIF WYARLLDLFA VNQHAGPYLT
MIGKMTANMF YIVVMMAIVL LSFGVSRKAI LSPEEPPSWT LARDIVFQPY WMMFGEVYAG
EIDVCETNQD CPPGSFLTPF LQAVYLFVQY IIMVNLLIAF FNNVYYDLKS ISNKLWKYNR
YRYIMTYHDK PWLPPPFILL SHIGLLINRI FHHRPTNESD QEEGDVGLKL YLSDEELKKL
HDFEEQCVEK YFHEKNESLN SSDSERIRLT TERLEEMFLQ LKEVHEKVFY IKESLISLDS
QLGHLQDLSA LTVDILKVLS AVDTLQVEEA LLADTKCRSY RKLPHSWSNV LYSKTLSSLE
CLYDKKYHYY SMPPSLLRSL VRSQWSSECK DHKLRTESNK VVEDSSRKIE IESDTLTSGI
SSETKSTPRY GQFLLVPPDH QGGPFSEDVT LNLSFSSTPT NIAVQQNMQS VSLIDKEPEG
YQWSQTDFVI HLPSKKTNAV EADHPLSLHP PLDDGENVIP CCDDREETEG GYVNWGFSEG
DEKGVFSSRK KQKKAPCIQS TYNCDGNCKD SPPRHVQIKE SKSFSYNSRS SQHSIISENK
LKHTSFWISP LWRNWGVCRS NSLPSSQKEK SGKTCKARGG NKNMLVVLSV SCQVIRVDDC
PQNTQVSSEP AEINIWDEEE KHSKNWLTVS NFSQYHGHLK ESYWLGRTQT AIRRSDGEPH
CSLLGFVHYS KTLSDIFESQ LACSSSIAVK SVLFAAVERN NLMRLAQTIP FTPVQLFAGE
EVTVYRLEES SPMNLDKSMS SWSQRGMAAM IQVLSREEMD GGLRRAMKVV CTWSENDVLK
LGQVFIVKSF LPEVVQAWQK IFHDGTVLHL CLREIQQQRA AQKLIYTFNQ VKPHTIPYTP
RFLEVFLIYC HSANQWLTIE KYMTGEFRKY NNNNGDEITP SSLLEELLLA FSHWTYVYTR
GELLVLDLQG VGENLTDPSV IKPEDKRSGK MVFGPANLGE DAIRNFITKH RCNSCCRRLK
LPDLRRNDCT MERLRPAFGE VEANARETDD ADEPLEYDTR L
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