ID   U3J5B3_ANAPP            Unreviewed;       807 AA.
AC   U3J5B3;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   05-JUN-2019, sequence version 2.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=phospholipase A2 {ECO:0000256|ARBA:ARBA00013278};
DE            EC=3.1.1.4 {ECO:0000256|ARBA:ARBA00013278};
GN   Name=PLA2G6 {ECO:0000313|Ensembl:ENSAPLP00000014690.2};
OS   Anas platyrhynchos platyrhynchos (Northern mallard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC   Anatinae; Anas.
OX   NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000014690.2, ECO:0000313|Proteomes:UP000016666};
RN   [1] {ECO:0000313|Ensembl:ENSAPLP00000014690.2, ECO:0000313|Proteomes:UP000016666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT   "A new Pekin duck reference genome.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAPLP00000014690.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC         glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC         ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00023422};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802;
CC         Evidence={ECO:0000256|ARBA:ARBA00023422};
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DR   AlphaFoldDB; U3J5B3; -.
DR   Ensembl; ENSAPLT00000015473.2; ENSAPLP00000014690.2; ENSAPLG00000014840.2.
DR   GeneTree; ENSGT00940000158756; -.
DR   OMA; DYWIPSD; -.
DR   Proteomes; UP000016666; Chromosome 1.
DR   GO; GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07212; Pat_PNPLA9; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR047148; PLPL9.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR24139:SF34; 85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2; 1.
DR   PANTHER; PTHR24139; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF01734; Patatin; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 8.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 4.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW   ProRule:PRU00023}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          153..185
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          220..252
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          317..349
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          350..382
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          483..667
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          413..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   807 AA;  89113 MW;  276AF395609B32EC CRC64;
     MQFLGRLVST LSGVAQALGS PHRVREVPAA EYGPGRCPLG QEGRLRLYGP GPGRSWDCVL
     LCPHSPQLAL RLFQLDDEAE ALQLFQHYAG HLRPFYESSP EPLTPEQLQQ LCDCLRGHPG
     WSPAHVAVEL GLLEAFRHNG VLGCVNNPDA GEDGCTPLHL ACRKGDVPCL LELLECRARV
     DVADRRGETV FHYAVRGHNP QVVEILGRTP TVVLDHLSHE GLTPLHLACQ LGKEDMVRSL
     LKCQASCGVV GTLGYPIHTA LKYSHKGCAQ AILEVDASQV RSRDPRHNAT PLHWAKKAEM
     TQLLLKYGSE VNVSSRTADM ALHIAVRRGR FDCAMVLLTH GANTNARGQD GNTPLHLAMK
     HDRLDMIKAI VVFGGDVEIP NDFGETPGLL AARSSKGANR KVLLDLLQTV GTQRCHPPTP
     SSQSLPPSDA SFFLEGPSSP RSSFNSLGYG DLLYASATLG QFLKTPDVMD SPREGGRSYD
     RLLCLDGGGI RGLVLIQLLL AIEKAAGRPI REIFDWIAGT STGGILALAI VHGKPMDYMR
     CLYFRMKDMV FRGSRPYESE PLDEFLKKEF GENTKMTDVQ KPKVIVTGTL CDRQPAELHL
     FRNYPVPETK VSTEYKTTAS FKPLTRPEDQ LVWRAARCSG AAPTYFRPIG RFLDGGLLAN
     NPTLDAMAEI HEYNKSLIKK GQRQKVRKLG LVVSLGTGKP PQVPVSSVDV FRPSNPWELA
     KTVFGARELG KMVVDCCTEA DGPAVDRARA WCEMTDIPYF RLSPQLHTDV MLDEVNDAVL
     VDALWDTQLY IYQQREQLER LVRDLCR
//