ID U3J6D9_ANAPP Unreviewed; 457 AA.
AC U3J6D9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2019, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Caspase 8 {ECO:0008006|Google:ProtNLM};
OS Anas platyrhynchos platyrhynchos (Northern mallard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8840 {ECO:0000313|Ensembl:ENSAPLP00000015066.2, ECO:0000313|Proteomes:UP000016666};
RN [1] {ECO:0000313|Ensembl:ENSAPLP00000015066.2, ECO:0000313|Proteomes:UP000016666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Hou Z.-C., Zhou Z.-K., Zhu F., Hou S.-S.;
RT "A new Pekin duck reference genome.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSAPLP00000015066.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR AlphaFoldDB; U3J6D9; -.
DR STRING; 8840.ENSAPLP00000015066; -.
DR Ensembl; ENSAPLT00000015856.2; ENSAPLP00000015066.2; ENSAPLG00000015210.2.
DR GeneTree; ENSGT00940000164225; -.
DR HOGENOM; CLU_036904_4_2_1; -.
DR OMA; CSGHLEM; -.
DR Proteomes; UP000016666; Chromosome 7.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08334; DED_Caspase_8_10_r2; 1.
DR CDD; cd08333; DED_Caspase_8_r1; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR033170; Caspase-8_DED1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF3; CASP8 AND FADD-LIKE APOPTOSIS REGULATOR A-RELATED; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PIRSF; PIRSF038001; Caspase_ICE; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000016666};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 4..82
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 102..179
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 218..341
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 362..447
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT COILED 163..190
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 457 AA; 52303 MW; E04EB999A9009287 CRC64;
MSTVFHKLLF DISEALATDE LAALKFLSLE HVPVRKQEAI EEPKAFFEVL QEKDMIKVGD
VSFLKELLYR INRIDLLAGQ LGSSREEMER ELQIPGRAKV STYRQLLYGI AEDLTPEDVK
SVKFLLQERI RKNKLQDNAS MLKVLMEMER NGIIKEDDLR ILKDILKEFR ADLKKRIDIY
EEKTKENNSK EELSNLICVS RHPAGQGLME SYKMENNPHG YCVILNNHKF KNPCENREGT
IEDGNALKRV FEWLQFETVE HMDLEAKKIY ETVKEYSKKN HSNMDCFVCF ILSHGEKDKI
KGTDDEFVNI KDLLTCFSGS NCPSLAGKPK LFFIQACQGS VGHPAVTVQE DCSGHLEMDA
VPLPSIPDQA DVLVGMATVE DFECYRCIRT GSVYIQCLCD KMELLCPLRK DIVTILTEVN
KEVGKKVLNG SKQMPKITST LRKQFIFQIP QCQSTIK
//
