ID U3JB38_DANRE Unreviewed; 682 AA.
AC U3JB38; A0A8M2BK84;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Exocyst complex component 7 {ECO:0000256|ARBA:ARBA00026169, ECO:0000256|RuleBase:RU365026};
DE AltName: Full=Exocyst complex component Exo70 {ECO:0000256|RuleBase:RU365026};
GN Name=exoc7 {ECO:0000313|Ensembl:ENSDARP00000127460,
GN ECO:0000313|RefSeq:XP_005173037.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-2752};
GN Synonyms=zgc:56575 {ECO:0000313|RefSeq:XP_005173037.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000127460};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000127460, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127460};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000127460}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000127460};
RG Ensembl;
RL Submitted (SEP-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005173037.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005173037.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000256|RuleBase:RU365026}.
CC -!- SIMILARITY: Belongs to the EXO70 family.
CC {ECO:0000256|ARBA:ARBA00006756, ECO:0000256|RuleBase:RU365026}.
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DR EMBL; FP102121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005173037.1; XM_005172980.4.
DR Ensembl; ENSDART00000152880; ENSDARP00000127460; ENSDARG00000087229.
DR Ensembl; ENSDART00000152880.3; ENSDARP00000127460.1; ENSDARG00000087229.5.
DR GeneID; 406723; -.
DR AGR; ZFIN:ZDB-GENE-040426-2752; -.
DR CTD; 23265; -.
DR ZFIN; ZDB-GENE-040426-2752; exoc7.
DR OrthoDB; 903986at2759; -.
DR Proteomes; UP000000437; Chromosome 12.
DR Bgee; ENSDARG00000087229; Expressed in testis and 28 other cell types or tissues.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0021537; P:telencephalon development; IMP:ZFIN.
DR Gene3D; 1.20.1280.170; Exocyst complex component Exo70; 2.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR004140; Exo70.
DR InterPro; IPR046364; Exo70_C.
DR PANTHER; PTHR12542:SF41; EXOCYST COMPLEX COMPONENT 7; 1.
DR PANTHER; PTHR12542; EXOCYST COMPLEX PROTEIN EXO70; 1.
DR Pfam; PF03081; Exo70_C; 1.
DR Pfam; PF20669; Exo70_N; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Exocytosis {ECO:0000256|RuleBase:RU365026};
KW Protein transport {ECO:0000256|RuleBase:RU365026};
KW Proteomics identification {ECO:0007829|PeptideAtlas:U3JB38};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365026}.
FT DOMAIN 312..675
FT /note="Exocyst complex subunit Exo70 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03081"
FT REGION 249..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4..31
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 682 AA; 77984 MW; 5BE489DE05CC18EE CRC64;
MIPTEDASAR KREIEEKLKQ EQETLSFIRE SLEKSDQLTK GMVSILSSFE SRLMQLENSI
IPVHKQTENL QRLQENVDKT LSNMDHVISY YHVAKDTDKI IREGPAGRLY EYLACIAKIQ
KAVEYFQDNN PDSPELNTVK ARFEKGKELL EAEFRSLLTR YSKPVPPVLI LDAIGGDEDM
EVQEEVTLEH LPEAVLQDII CISAWLVEYG RNQDFMNVYF QVRSSQLDRS IKGLKEHFRK
NSATSAIHSP AVQTKRKETP TKKAPKRPGT IRKAQNLLKQ YSQHGLDGKK GSNLTPLEGK
DDVLDIEIDS YIHCISAFVK LAQSEYALLT EIIPEHHQKK TFDSLIQEAL DNLMLEGDNI
VSAARRAIMR HDYSAVLTIF PILRHLKQTK PDFDATLQGT AASTKNKLPA LITSMETIGA
KALEEFADSI KNDPDKEYNM PKDGTVHELT SNAILFLQQL LDFQETAGAM LASQESSSSA
SSYSSEFSRK LLSTYIYKVL GNLQLNLSNK AKVYEDPALR AIFLHNNYNY ILKSLEKSEL
IQLVAVTVKK VESSYRELIE QEIQNYQRSW LRVTEHLAER NIPDFQPGAK LKDKERQIIK
DKFKGFNDGL EELCKIQKGW AVPDKEQRDT IRHAQKRVVS LTYKAFLQRC ANISFTKNPE
KYHRYSPEQV EDMIDRLFDT SA
//
