ID U3JFC9_FICAL Unreviewed; 455 AA.
AC U3JFC9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Kynurenine aminotransferase 1 {ECO:0000313|Ensembl:ENSFALP00000001483.2};
GN Name=KYAT1 {ECO:0000313|Ensembl:ENSFALP00000001483.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000001483.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000001483.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000001483.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-kynurenine = H2O + kynurenate + L-
CC glutamate; Xref=Rhea:RHEA:65560, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959,
CC ChEBI:CHEBI:58454; EC=2.6.1.7;
CC Evidence={ECO:0000256|ARBA:ARBA00023912};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:65561;
CC Evidence={ECO:0000256|ARBA:ARBA00023912};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an S-substituted L-cysteine + H2O = a thiol + NH4(+) +
CC pyruvate; Xref=Rhea:RHEA:18121, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:29256, ChEBI:CHEBI:58717; EC=4.4.1.13;
CC Evidence={ECO:0000256|ARBA:ARBA00023937};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18122;
CC Evidence={ECO:0000256|ARBA:ARBA00023937};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Amino-acid degradation; L-kynurenine degradation; kynurenate
CC from L-kynurenine: step 1/2. {ECO:0000256|ARBA:ARBA00024016}.
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DR RefSeq; XP_005055584.1; XM_005055527.1.
DR AlphaFoldDB; U3JFC9; -.
DR STRING; 59894.ENSFALP00000001483; -.
DR Ensembl; ENSFALT00000001492.2; ENSFALP00000001483.2; ENSFALG00000001422.2.
DR GeneID; 101809203; -.
DR KEGG; fab:101809203; -.
DR CTD; 883; -.
DR eggNOG; KOG0257; Eukaryota.
DR GeneTree; ENSGT00940000158797; -.
DR HOGENOM; CLU_017584_4_0_1; -.
DR Proteomes; UP000016665; Chromosome 17.
DR GO; GO:0047804; F:cysteine-S-conjugate beta-lyase activity; IEA:Ensembl.
DR GO; GO:0016212; F:kynurenine-oxoglutarate transaminase activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR CDD; cd00609; AAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR43807; FI04487P; 1.
DR PANTHER; PTHR43807:SF14; KYNURENINE--OXOGLUTARATE TRANSAMINASE 1; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 60..441
FT /note="Aminotransferase class I/classII"
FT /evidence="ECO:0000259|Pfam:PF00155"
SQ SEQUENCE 455 AA; 51219 MW; 4949E7788466DB07 CRC64;
MLRRAGPSLR HFWLERNSGA GHSSCSREAK MSKPVQARRL EGIDKNIWVE FVKLATTYSK
VNLGQGFPDF PAPDFLTEAL ARALGGGNHM LHQYTRAFGH PPLVKVLAQF FEKLLGRDLD
PMTNVMVTVG AYQALFCCFQ ALVDEGDEVI IIEPFFDCYE PMVKMAGGTP VFVPLRPNPP
KDGKLMSSAD WQLDPAELAS KFSERTKAIV LNSPNNPLGK VFSRGELGLI AELCVKHDVL
CISDEVYEWL VYDGKQHIRI ASLQGMWDRT VIVGSAGKTF SATGWKVGWV VGPDRLLQHL
RTVHQNSVYH CATVAQEAVA QGFQRELTLY GKPESYFVQL PKELQRKRDW LVQSLDDVGM
KPIIPEGTYF LVADISQFKS DVPDVPNSDE PYDYRFTKWM VKNKGLAAIP LSAFYSEAHK
NNYTNFIRFC FAKEEATLKA ANDILQKWKQ EKSSS
//
