ID U3JHI0_FICAL Unreviewed; 589 AA.
AC U3JHI0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Acid sensing ion channel subunit 1 {ECO:0000313|Ensembl:ENSFALP00000002234.2};
GN Name=ASIC1 {ECO:0000313|Ensembl:ENSFALP00000002234.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000002234.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000002234.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC1 subfamily. {ECO:0000256|ARBA:ARBA00038517}.
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DR AlphaFoldDB; U3JHI0; -.
DR Ensembl; ENSFALT00000002246.2; ENSFALP00000002234.2; ENSFALG00000002144.2.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000158414; -.
DR HOGENOM; CLU_020415_1_2_1; -.
DR OrthoDB; 3415680at2759; -.
DR Proteomes; UP000016665; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 2.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 2.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF170; ACID-SENSING ION CHANNEL 1; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 107..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 589 AA; 66614 MW; 9BEBA04A074992C7 CRC64;
MNICICACVC VYVYIYICIC IFRLGGKSRA QQSICPPWAG HPPGTHGLPS PQSGHPGVLA
LTMMDLKVDE EEVDSGQPVS IQAFASSSTL HGLSHIFSYE RLSLKRVVWA LCFLGSLALL
ALVCTNRIQY YFLYPHVTKL DEVAATRLTF PAVTFCNLNE FRFSRVTKND LYHAGELLAL
LNNRYEIPDI QTADEKQLEI LQDKANFRNF KPKPFNMLEF YDRAGHDIRE MLLSCFFRGE
QCTPEDFKVV FTRYGKCYTF NAGQDGKPRL ITMKGGTGNG LEIMLDIQQD EYLPVWGETD
ETSFEAGIKV QIHSQDEPPL IDQLGFGVAP GFQTFVSCQE QRLIYLPPPW GDCKAVAGDS
EFYDTYSITA CRIDCETRYL VENCNCRMVH MPGDAPYCTP EQYKECADPA LDFLVEKDNE
YCICEMPCNM TRYGKELSMV KIPSKASAKY LAKKYNKSEQ YIGENILVLD IFFEALNYET
IEQKKAYEVA GLLGDIGGQM GLFIGASILT VLELFDYAYE VIKHRLCRRG KCRKNHKRNN
TDKGVALSMD DVKRHNPCES IRGHPAGMTY AANILPHHPA RGTFEDFTC
//
