ID U3JHQ5_FICAL Unreviewed; 547 AA.
AC U3JHQ5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Ral GEF with PH domain and SH3 binding motif 1 {ECO:0000313|Ensembl:ENSFALP00000002309.2};
GN Name=RALGPS1 {ECO:0000313|Ensembl:ENSFALP00000002309.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000002309.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000002309.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000002309.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; U3JHQ5; -.
DR STRING; 59894.ENSFALP00000002309; -.
DR Ensembl; ENSFALT00000002321.2; ENSFALP00000002309.2; ENSFALG00000002222.2.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000154079; -.
DR HOGENOM; CLU_021333_0_1_1; -.
DR Proteomes; UP000016665; Chromosome 17.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF167; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 50..289
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 322..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61268 MW; F09DD769B8AB3FD3 CRC64;
MYKRNDLMAN VMVTSATPEG SSSSDSLEGR SSDYANKSYD AVVFDVLKVT PEEFASQITL
MDMPVFKAIQ PEELASCGWN KKEKHTLAPN IVAFTRRFNQ VSFWVVREIL TAQTLKIRAE
ILSHFVKIAK KLLELNNLHS LMSVVSALQS APIFRLTKTW ALLNRKDKTT FEKLDYLLSK
EDNYKRTREY IRSLKMVPTI PYLGIYLLDL IYIDSAYPAS DSIMENEQRS NQMNNILRII
ADLQVSCNYD YLTTLPHVQK YLKSVHYIEE LQKFVEDDNY KLSLRIEPGN SSPRLVSSKE
DLAGPSDMSA IMKFSRRPTC PDASVAASLP TPPVPRHRKS HSLGNNMMCQ LSVVESKSAT
FPTERPRHLL DDSVLESHSP APGPAAGARL ANGLSIDSSE SSEFSEELPS GLERGRLYAT
LGPNWRVPIR NSPRSRSCVY SPTGACSCTA GGSTGVITME GPLRRKTLLK EGKKPTLSSW
TRYWVMLSGS TLLYFGAKAL RGTERKHYKS TPGKKVSIVG WMVALPDDPE HPDIFQLNNP
DKGNNLQ
//
