ID U3JJL7_FICAL Unreviewed; 3249 AA.
AC U3JJL7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Assembly factor for spindle microtubules {ECO:0000313|Ensembl:ENSFALP00000002971.2};
GN Name=ASPM {ECO:0000313|Ensembl:ENSFALP00000002971.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000002971.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000002971.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000002971.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 59894.ENSFALP00000002971; -.
DR Ensembl; ENSFALT00000002984.2; ENSFALP00000002971.2; ENSFALG00000002825.2.
DR eggNOG; KOG0165; Eukaryota.
DR GeneTree; ENSGT00560000077332; -.
DR HOGENOM; CLU_000237_0_0_1; -.
DR Proteomes; UP000016665; Chromosome 8.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072687; C:meiotic spindle; IEA:Ensembl.
DR GO; GO:0036449; C:microtubule minus-end; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0008356; P:asymmetric cell division; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0021873; P:forebrain neuroblast division; IEA:Ensembl.
DR GO; GO:0051661; P:maintenance of centrosome location; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0090306; P:meiotic spindle assembly; IEA:Ensembl.
DR GO; GO:0045769; P:negative regulation of asymmetric cell division; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0048477; P:oogenesis; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0051445; P:regulation of meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0051653; P:spindle localization; IEA:Ensembl.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 35.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 39.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 68.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 18.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 46.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT DOMAIN 881..1017
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1069..1222
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3198..3249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3249 AA; 379129 MW; A0FCF79214BF9035 CRC64;
MAEGSVTAEA RGDRDRNPAK NPGRRRWALR GGEEDEDEEP VLVLSYFSRP PFLSFGRLRV
GASRTRLLCI DNPNDDDAEV VIERFPAAAR GFSIEQRRFF VEAGQRIFVS ITWTPLEEGK
IRELVTFVVN DVVKHQAVLL GAAEQLPKKK KSLWDTIKKK NSSGTSAIKV KKSTLEIKNV
NKTFQVSQKV DRLRNPLQSC ENQDTVQNSV SQGNDPLAGS ENQLPPSPIA PVPEEKGNTV
HTPLALRRST TFGDIAASGN KELLPKIDIC NIDKCVTEHS QLQPESASSS AGLAQLPISS
DGGVLNFTLS PVSTPEHSAC APVLSTRRIL SPDAFVNDNY QVDIDVIEQP FPILSPDQFV
KDSLSDKPSK TPKPEAALIS STTETYVVKR FLPSKWKKDG GVKTETHVHV EHSLNEVLEL
HNVKSQAFDS DKPKEDHCSF PSAKELQTDN PPRREQTKKR PILSATVIKS KPAATEKTRT
ETCQPKSKKC LNKAIIGCAN VMPGYVEAET SKHLPVTAPI SSENKCQNDK VNSLPTGSTS
SCRKRKSETY VENSKATAPV HVEEVERKRA LTSSMSNQTR TTRRPLAFVP MSGERVGHRK
KAGSSLQKAS KATKRISKPV PGLAQSHLTF VKPLKTVIPR HPMPFAAKNM FYDERWKEKQ
QRGFTWWLNF VLTPDDFNVK TNTSQVNAAA LVLGEESHHK RSLAKAPTKD EASLKAYTAR
RKLNRLRRAA CQLFTSPAMV TAIRKLEGEI ETRRLLVRRD RHLWKDIGER QKVLNWLLSY
NPLWLRIGLE TIYGELIALE SNSDVMGLAI FILNRLLWNP DIAAEYRHPV VPHLYREGHE
EALSKFTLKK LLLLVCFLDC AKRSRMIDHD PCLFCKDAEF KASKDLLLAF SRDFLSGEGD
LSRHLGFLGL PVSHIQTPLD EFDFAVTNLA VDLQCGIRLV RTVELLTKNW SLSKQLRVPA
ISRLQKMHNV DIVLNVLKER GVHLKDETGA SIDSRDIVDR HRERTLALLW KIVFAFQVDV
FLNVEHLKEE IEFLKNTHKR KALLGAVKTF PNDFQVQEDS SNFSSQTYSE NVKLLMAWVN
AVCRFYNIKV ENFTVCFSDG RVLCHLIHHY HPCYMPLEAV CQRTTQTVEC SRTVTVGLNS
SASSESDTSL NVVEEMFDQT LTPSVLYKEL LDNEKQNFQL INAAVSDLGG IPAMIHHADM
SNTIPDEKVV ITYLSFLCSR LLDLRQETRA ARLIQAAWRN YRLKKELKLS QERDRAARII
QKSAMNFLAR RRILRKENAA IFIQKHWRGY LARMTLFNLK KAKLEEARNR SATIIQAYWR
RYSARKRYLQ LRHCVIFVQA RIRMVKSVAA YKRIVWATVT IQRHLRATRL AKIDRQRYEI
LKSSALTIQS AFRRWRRYKI QQKIKAALVI QNYFRKWQSS KLAKRRRAAL VIQCWYRMHR
DLKNYLHVKQ NVIKIQAWYR CQLARRVYQE HRAKIMIIQQ YYRAYKLGKA ERKSYLQKRA
AVIVLQAAFR GTKAREQYRQ TKAACVIQSL WRMKREKQRF LQLKKSVTTL QSHVRKYQQV
KRYKEIKSAA STIQTRYRAH VAARKAAAAF QRVRLAAVVL QAAYRGMQAR RQARVLRSVI
RIQSSFRAYV ARKRFKSLRG AAVKIQALTK MRQVRKRYCA LRAATLYVQR RYRSQRHALQ
VKEDYRKLKR GCIRIQALVR GYFVRKQMQR WREAAVLLQA CYRMKRDRQQ YLRIYSAAIV
IQQCYRACKK SRCHRQEFLQ VRKAAVCLQA AYRGYKTRKR LKLECRAAVK IQTAFRAHAA
RVKHKAMVQA SIVIQRWYRN CKGGKRQRLN FLMTRAAVLS LQAAFRGWKV RKQIQRQRAA
ATRIQSTFRR FMAVKKFRLV KHAVLTIQRH YRAKVLGQRQ RQEYIQLQNA VVHLQALWRG
KAVRRMIQRE HHLATIIQSY YRMHVNQLKY KKLRQATLVI QKYYRAYCMK KTQRAVYVKT
KAAVLVLQSA YRGMTVRRRL NKLNKAATAI QAAFKSYLAK KEYERFRSAA IAIQRRYRAV
IHAKCQRQRY LSLKRATVQV QAIYRGVRVR RQVQCMHQAA ACIQATFKMY FMSKKYQSMK
MAAIRIQRQY RAFCLGKVQR KKYLELKKSV IILQAACRGM KVRQDLKTMH QSAAIIQSYY
RMHKQQRDFR KLLLATRQIQ QWFRACKERD AEVHNYVILK NAVLRIQAAF RGMKTRRLIR
TMNESAVIIQ RRFRTFLERK CFLSMKSAAV VIQRKYRATK LANIQRQKYI SLLNAAVIIQ
SAYRGFVVRK KMQQMHQAAT VIQAMLRMHK IYTSYQALRL ASVIIQQCYR AYREGKRERE
KYLKLYNSVL VLQAAYRGMK TRCFLKRQHE ATLIIQRNYR MYRQYCHYRR VKWAAQLIQE
RYRAHRLRKI AVERYTSLKK AATCIQRAFR DMRARKRERE MHRAATVLQK NFKAFRERQR
FLSLKAATLV LQRRYRALAL ARQHALEYRS LRRAAIHIQA VYRGVRVRRS LEHMHSAAST
IQAAYRMLRD RRAYQNMRIA AVVIQNYCRA YLKGKNQREQ YLTMRNSVLV IQAAYRGMKA
RQELKLLHLS AVVIQSSYRM HVQRRYYKQL CWAATVTQQR FRAKMAREAA MRNYAEIRKA
AICLQAAFRA RKARQLYKAE VAARRIQSLL RARVQRRRFL AQRAAAVVIQ SAFRRHRARA
RYALLRSAAA ALQRWYRSCL GARSQRAEYL AQRQAAVVIQ SAFRAMKARR AARQLRAARK
IQSFLRMALE RRKYLQLRAA AVTLQSYYLM HKCKSQYMSY KRAAVVLQRH YRSHLAVKQQ
RLAYLETRRS IILVQATVRG YIQRKRFHKM KESTIKIQPP FRGFIQRQKY LLCKFSAVLI
QQHYRAHRMR NIDQHRFHQM KKAAITIQAA YRGYKARQQW ISRMRAAQVI QAWFRGHKAR
KEYTSVLRAA LVVQSHFRAK ELRARFLKMK SCALTIQRVW RATRTARMLR QQFLAARSAA
VKIQLAYRQY RARRLLREKH QAACLIQNAY RGFKARRKFA QQKAAAVIIQ KHLRAWQEGR
LQFMKYNKTR RAVIKLQAFI RGYLVRKKIL EQKQKKRLLY FTAAAYHHIS AIKIQRAYRI
HLTLKLAQTQ ISSVLIIQSW FRGRAQRRRF LRXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXAAPQGPRR RRHPEGRAPL PRPPAPQETR AGSRQISGFV
EGIFLEKDD
//
