ID   U3JKS3_FICAL            Unreviewed;       508 AA.
AC   U3JKS3;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase {ECO:0000256|ARBA:ARBA00026102};
DE            EC=3.6.1.62 {ECO:0000256|ARBA:ARBA00026102};
GN   Name=DCP1B {ECO:0000313|Ensembl:ENSFALP00000003377.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003377.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000003377.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000003377.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside
CC         in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) +
CC         N(7)-methyl-GDP; Xref=Rhea:RHEA:67484, Rhea:RHEA-COMP:15692,
CC         Rhea:RHEA-COMP:17167, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:63714, ChEBI:CHEBI:138282, ChEBI:CHEBI:156461;
CC         EC=3.6.1.62; Evidence={ECO:0000256|ARBA:ARBA00024496};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67485;
CC         Evidence={ECO:0000256|ARBA:ARBA00024496};
CC   -!- SIMILARITY: Belongs to the DCP1 family.
CC       {ECO:0000256|ARBA:ARBA00008778}.
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DR   AlphaFoldDB; U3JKS3; -.
DR   Ensembl; ENSFALT00000003390.2; ENSFALP00000003377.1; ENSFALG00000003240.2.
DR   GeneTree; ENSGT00940000158409; -.
DR   Proteomes; UP000016665; Chromosome 1A.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010334; Dcp1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR16290:SF5; MRNA-DECAPPING ENZYME 1B; 1.
DR   PANTHER; PTHR16290; TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1; 1.
DR   Pfam; PF06058; DCP1; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
SQ   SEQUENCE   508 AA;  54948 MW;  69BBECD24BBEB915 CRC64;
     MNRLSMENRT EPITKDLDFQ LQDPFLLYRN ARLSIYGIWF YDKEECQRIA ELMKNLTQQE
     QFKAQQGTGS GVSPMIMNSA NNKEVDILRM LTKAKDEYTK CKTCSEPKQI TSSSAIYSNP
     NLIKPIPVKP SETQHQRISQ QSKGVDPEPQ HLSLTALFGK QDKADGCEPL NKQHQESLPA
     RQGVVRSLSY EEPSRHSPCA EKQLCPAIQK LMVRGTELHP LAEFPESRLC ENGSVPPAGD
     TFTGLFQPVT SHGVAAGAQD AAGAQSLLHK LQSQSGSVAK VDPSATGAVN STVSVFSRTP
     APVGASAAPV NNMSQPPLVY FNGSLPGQTL DGKEQSKLPR QPLPLSGNQT ANSGVISPQE
     LLKKLQIVQQ EQQLHVSSRP TLAAKFPVVT QNTNTLKPLD SWIEKAPGTE KQSTLFQVIS
     PQRIPATVTP TLLMSPMVFT QPTPAPPKAA ESGRLAAANP EPAAGSASLL LPLPAPEPAV
     ASSTSISKLQ LQETLLHLIQ SSLLKSRS
//