ID U3JKS5_FICAL Unreviewed; 2127 AA.
AC U3JKS5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSFALP00000003379.2};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSFALP00000003379.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003379.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000003379.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000003379.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR STRING; 59894.ENSFALP00000003379; -.
DR Ensembl; ENSFALT00000003392.2; ENSFALP00000003379.2; ENSFALG00000003242.2.
DR eggNOG; KOG1245; Eukaryota.
DR GeneTree; ENSGT00940000155359; -.
DR HOGENOM; CLU_000899_0_0_1; -.
DR Proteomes; UP000016665; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 674..745
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1023..1088
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1891..1941
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2036..2106
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1539..1566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1804..1825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1950..1991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 861..919
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 78..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..223
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..599
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 774..805
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1256
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1954..1991
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2127 AA; 234846 MW; 1164E2A9B5D1AF92 CRC64;
MESAERLTTS SVSSAAAAST PASSTPSVTS EVSKGGAATL SSTINTCEWW RTADTHSRPG
AAFFPPLLGI PTLFAPPAQN HDSASFHSRA TGKSSRSSTD KGINGSLNGN STSTVSALST
SVLSTGSAAS AGAVKAVTSG AAGRKYSQER SKVQLLDTRA DKIKDKKPRK KAVESSSNSD
SDSGSSSDTS SEGVSSSDSD DLEEDEEEEE DQSAEESEDD ESDSENEAHH KSKNKVLMHS
GVTDTKNDGQ KSQEKSQEKR THQQIPLVSD SQTHSSFQSQ QKQPQVLSQQ LPFIFQSSQA
KEESVNKHTS VIQSTGLVPN VKPLSLVHEA KKETYLKLIV PSPDLLKAGN KNTSEESLTL
TSDVRSKREQ YKQAFPAAQL KKQESSKSLK KVIAALSSPK PTSSSPAHQK LTSLENNHSN
PFLTNALLGN HQPNGVIQSV IQEAPLALTT KAKAQSRISE GAAVSSSAPF SLPINLSACG
KKTAGNRTAA MTSTSPVLPG SGKDKAVSNN AVNAVKPQHR LHSAKLVVEQ FRGVDSDAPS
SKDSDDSNDE DDDDEDEDED DEEDDSDDSQ SESDSNSESD TEGSEEEDDE DDKDQDESDT
DTEGEKTPLK LNKTSSSVKS SSIGLTAHST PLNLQVAKSS GSAPAALCPE SQPAVFLGTG
ASSLTPGISK RRRVADEREL RVPLDFGWQR ETRIRNFGGR LQGEVAYFAP CGKKLRQYPE
VVKYLSRNGI MDISRDNFSF SAKIGVGDFY EARDGPQGVQ WCLLKEEEVI PRIRAMEGRR
GRPPNPDRQH SREESRSRRR KGRPPNVGSG EFLDSADTKL LRKLQAQEIA RQAAQIKLLR
KLQKQEQARA AKEAKKQQAI MAAEEKRKQK EQIKIMKQQE KIKRIQQIRM EKELRAQQIL
EAKKKKKEEA ANAKLLEAEK RIKVSLEDNK FGMLFISNEE RERRRQHMML MKAMEARKKA
EEKERLKQEK RDEKRLNKER KLEQRRLELE MAKELKKPNE DMCLADQKPF PELPRIPGLI
LDGSTFSDCL MVVQFLRNFG KVLGFDVTVD VPSLSVLQEG LLNIGDSMGE VQDLLVKLVS
AAVCDPGLGT GHKAKTILGE HLLNVGINRD NVSEILQIFM EAHCGQTELT ESLKTKAFQA
HSPAQKASVL AFLVNELACS KSVVSEIDKN IDYMSNLRRD KWMVEGKLRK LRIIHAKKTG
KRDAAGSGDG GEEPHSLETP APGRKRRRKG GDSDDDDDDD DDSDDQADED DEDEEDKDDK
KGKKAEVCED EDEEDKDDKK GKKAEVCEDE DDGDQTASVE ELEKQIEKLT KQQSQYRKKL
FEASHCLRSM MFGQDRYRRR YWILPQCGGI FVEGMESGEG LEEIAKEKEK LKKEESMHIK
EEEFETEEKV HCLATSHCEQ KENLKEKDST NLFLQKPGSF SKLSKLLEVA KMPPESDIMS
PKPNGSAANG CTLSYPGNSK NSLCSLQAPA SQSSIEKSDS NNLFSPNASG PGKFYSSPLM
ANDQLLKTLS EKSRQWFSLL PRVPCDDTSV TRVDTAAAAA PLAPQSPPSK SPSPVPSPLL
GSTSAQSPMG LSPFALSPLQ QMKTGLPIMG LQFCGWPTGV LTSNVPFPSP LPALGSGLGL
SEVNGNSFLA SNVSASKSES PALQAERISS TPSTAAEVAK PVDYPNPKPI PEEMQYGWWR
ITDPEDLKSL LKVLHLRGIR EKALQKQIQK HMDYITLACI KNKDVAIIDI NENEDNQVTR
DVVENWSVEE QAMEMDLAIL QQVEDLERRV ASASLQVKGW LCPEPASERD DLVYREHKSI
TRLPKKHDGD CAGGGEGSAS SLERRSDNPL DIAVTRLADL ERNIERRTEE DIAPGLRVWR
RALSEARSAA QVALCIQQLQ KSIAWEKSIM KVYCQICRKG DNEELLLLCD GCDKGCHTYC
HRPKISTIPD GDWFCPACIA KASGQTLKIK KLQSKGKKSN EQKRSRKLAG ETEDEDSATT
SVALKRGKTD PKKRKVDENI CVSQLKQENC TSVKKPKRDG DSKDLAICSM ILSELETHED
AWPFLLPVNL KLVPGYKKVI KKPMDFSTIR DKLSSGQYPN LEAFSLDVRL VFDNCETFNE
DDSDIGRAGH NMRKYFEKKW TEIFKVS
//
