ID   U3JLR2_FICAL            Unreviewed;      1323 AA.
AC   U3JLR2;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 57.
DE   SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSFALP00000003716.2};
GN   Name=TSC2 {ECO:0000313|Ensembl:ENSFALP00000003716.2};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003716.2, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000003716.2, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000003716.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 59894.ENSFALP00000003716; -.
DR   Ensembl; ENSFALT00000003730.2; ENSFALP00000003716.2; ENSFALG00000003513.2.
DR   eggNOG; KOG3687; Eukaryota.
DR   GeneTree; ENSGT00950000183139; -.
DR   HOGENOM; CLU_001122_0_0_1; -.
DR   Proteomes; UP000016665; Chromosome 14.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003913; Tuberin.
DR   InterPro; IPR018515; Tuberin-type_domain.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   InterPro; IPR024584; Tuberin_N.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR   Pfam; PF11864; DUF3384; 1.
DR   Pfam; PF03542; Tuberin; 1.
DR   PRINTS; PR01431; TUBERIN.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665}.
FT   DOMAIN          43..458
FT                   /note="Tuberin N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11864"
FT   DOMAIN          545..891
FT                   /note="Tuberin-type"
FT                   /evidence="ECO:0000259|Pfam:PF03542"
FT   REGION          643..664
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1094..1120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1132..1167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1104..1118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1134..1148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1323 AA;  147416 MW;  D24AB41671E9E7CA CRC64;
     MAKPQSKDSG LKEKFRNLLG LGTSRGSSKS SEGKQTDAVG CGLSNRIRAI SQICEVAKTK
     KIEEHAVEAV WKVVADMLQP ERPAEARHAV LHLLKSIVQG QGERLGILRA HFFKVIKDYP
     SNEDLHERLE VFKALTENGR YITYLEEELA DFVLQWMDVG LTSEFLLVLV NLVKFNSCYL
     EDYVADMVHK ICLLCIQTSS SMDIEISLQV LDAVVCYNCL PSENLPVFII TLCRTINVKE
     LCEPCWKLMR NLLGTHLGHS AIYNMCRIME DRSYMADAAL LRGAVFFVGM ALWGAHRLNS
     LRNSPTSVLP SFLKAMTCPN AVVSYEIVLS ITRLIKKYGK ELQAVTWDIL LDIMERLLQQ
     LQVLESQELK SIVHDLLTTV EELCDQNDFH GSEERFFELV ERCADQRPES SVLNLITYRA
     QSIHPAKDGW IHNLQLLMER FFRNESRSAV RIKILDVLSF VLSINRQFYE EELINLVVIS
     QLAHIPEDKD HQVRKLATQL LVDLAEGCNT HHFNSLLDII EKVAAHSLSS PSELEERDLL
     SYSASLEDVK TAVLGLLIIL QTKLYSLPSS HATRVYEMLI QHVQRHYHYS YSLPVASSIR
     LQVFDFLLML RADSLHRLGL SNKDGAVRFS PYCLCDFAEK RTSEKKPPGT LSPPSGSPSV
     PSQGATVRVG HLPYSMVFGV LLQCLKQETD WKVLKLVLNK LPESLRYKVL FLTSPCNIDQ
     LASALSYMLT DKKTTDRLHG TPEGFSRTDL HLAVVPVLTA LISYHNYLDK AKQREIVYCL
     EHGLIYRCAN QCVVALSVCS VEMPDIIIKA LPVLIVKLTH ISATANMAIP LLEFLSTLAR
     LPHLYRNFAA EQYASVFAIS LPYTNPSKFN QYIVCLAHHV IAMWFIRCRL PFRKDFVPYI
     TKGLRSNVLL SFDDTPEKDS FRARSTSLNE RPKSLRLAKN AKQGLNNSPP VKELKEPSAV
     DAFRSRSISV SEHVVRSRIQ TSITSSSLGS ADENSMAQAD DNLKNLHLEL TETCLDMMAR
     YVFSNFTAVP KRSPVGEFLL AGGRTKTWLV GNKLVTITTS VGTGTRSLLG LDSGEFQSTP
     ESSSDPVLQV RQTKEAPAKL ESQAGQQVCR SSRNRVRSMS GGHALRVGAL DSSASHFPSG
     SASQGTQGPA APAARPDKAS PAPQTALQKE KANLAAYVPL LTQGWAEILV RRPTGNTSWL
     MSLENPLSPF SSDINNMPLQ ELSNALMAAE RFKEHRETAL YKSLSVPSSS LATGTAKPSL
     LQRSNTVASF SSMYQSSCQG KLHRSISWLP VVRRAACAAG QAPLGAAQPT GICQNWAQKD
     KSR
//