ID U3JLZ8_FICAL Unreviewed; 843 AA.
AC U3JLZ8;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Circadian locomoter output cycles protein kaput {ECO:0000256|ARBA:ARBA00040572};
GN Name=CLOCK {ECO:0000313|Ensembl:ENSFALP00000003802.2};
OS Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000003802.2, ECO:0000313|Proteomes:UP000016665};
RN [1] {ECO:0000313|Ensembl:ENSFALP00000003802.2, ECO:0000313|Proteomes:UP000016665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23103876; DOI=10.1038/nature11584;
RA Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA Wolf J.B.;
RT "The genomic landscape of species divergence in Ficedula flycatchers.";
RL Nature 491:756-760(2012).
RN [2] {ECO:0000313|Ensembl:ENSFALP00000003802.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
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DR AlphaFoldDB; U3JLZ8; -.
DR STRING; 59894.ENSFALP00000003802; -.
DR Ensembl; ENSFALT00000003817.2; ENSFALP00000003802.2; ENSFALG00000003646.2.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00940000157580; -.
DR HOGENOM; CLU_010044_2_2_1; -.
DR OrthoDB; 2899615at2759; -.
DR Proteomes; UP000016665; Chromosome 4.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd19734; bHLH-PAS_CLOCK; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF2; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 34..84
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 107..177
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 285..332
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 420..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 529..563
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 426..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 94689 MW; 24A9C69EBF599E0D CRC64;
MFFTISTHKM SSIADRNDGS IFDGLVEEDD KDKAKRVSRN KSEKKRRDQF NVLIKELGSM
LPGNARKMDK STVLQKSIDF LRKHKEITAQ SDASEIRQDW KPTFLSNEEF TQLMLEALDG
FFLAIMTDGN IIYVSESITP LLEHLPSDLV DQSVFNFIPE GEHSEIYKIL SSHLLESDSL
TPEYLKSKNQ LEFCCHMLRG TIDPKEQPTY EYVKFIGNFK CLNHVPNSAH NGFEGTIQRS
HRPSYEEKVC FVATVRLATP QFIKEMCTVE EPNEEFTSRH SLEWKFLFLD HRAPPIIGYL
PFEVLGTSGY DYYHVDDLDN LAKCHEHLMQ YGKGKSCYYR FLTKGQQWIW LQTHYYITYH
QWNSRPEFIV CTHTVVSYAE VRAERRRELG IEESLPEITA DKSQDSGSDN HINTVSLKEA
LERFDTSPTP SASSRSSRKS SHTAVSDHSS TPTKMTVDTS TPPRQSLSGH EKTAQRRSSL
SSQSLSSQSL GQPVTQPAIS QPAALQLQSG MTQPVFQFSA QLGAMQHLKD QLEQRTRMIE
ANIHRQQEEL RKIQEQLQIV HGQGLQMFLQ QSSSGLNFGS VQLPSGNSST VQQLPPINMQ
GQVVQTNQTQ SGMNTGHIST PHMIQQQPLQ STATQHNQQN VLSGHNQQSS LASQSQNTVS
APLYNTMVIS QPTAGNVVQV PSSLPQNNNQ NAAAVTTFTQ DRQIRFSQGQ QLVTKLVTAP
VACGAVMVPS TMFMGQVVTA YPTFAAQQQQ TQTLSITQQQ QQQQQQQQQQ SQQDHQQQLT
TVQQPAQSQL TQHPQQFLQV TSWKSVGSAY SLCCFPTTTK HFHSVPPPAA SVSAAAAAVT
TQN
//
