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Database: UniProt
Entry: U3JMQ0_FICAL
LinkDB: U3JMQ0_FICAL
Original site: U3JMQ0_FICAL 
ID   U3JMQ0_FICAL            Unreviewed;      2692 AA.
AC   U3JMQ0;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   16-JAN-2019, entry version 34.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSFALP00000004054};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSFALP00000004054};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000004054, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000004054}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
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DR   EMBL; AGTO01001588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFALT00000004072; ENSFALP00000004054; ENSFALG00000003887.
DR   GeneTree; ENSGT00940000156039; -.
DR   OMA; ENQVKGG; -.
DR   Proteomes; UP000016665; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2220   2242       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2254   2273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2294   2318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2338   2366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2387   2409       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2513   2536       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    215       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      223    279       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      286    365       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      371    427       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       81    101       {ECO:0000256|SAM:Coils}.
FT   COILED     2623   2671       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2692 AA;  306475 MW;  5BD8923F6F9A453E CRC64;
     MVKEKVSGLS IPCWLLQTFG FLRLVDDRCV VQPEAGDLAN PPKKFRDCLF KVCPMNRYSA
     QKQYWKAKQA KQGNHTEAAL LKKLQHAAEL EQKQNESENR KLLGEIVKYS NVIQLLHIKS
     NKYLTVNKRL PALLEKNAMR VSLDAAGNEG SWFYIQPFWK LRSEGDNVVV GDKVVLMPVN
     AGQPLHASNI ELLDNPGCKE VNAVNCNTSW KITLFMKFSS YRDDVLKGGD VVRLFHAEQE
     KFLTCDEYEK KQHIFLRTTL RQSATSATSS KALWEIEVVH HDPCRGGAGQ WNSLFRFKHL
     ATGNYLAAEL NPHYPEGNNE GKALQRDGDL PASKKKRQAG EKIMYTLVSV PHGNDIASLF
     ELDATTLQRA DCLVPRNSYV RLRHLCTNTW VTSTSIPIDT EEERPVMLKI GTCQTKEDKE
     AFAIVSVPLS EVRDLDFAND ANKVLASTVK KLENGTITQN ERRFVTKLLE DLIFFVADVP
     NNGQEVLDVI VTKPNRERQK LMREQNILAQ IFGILKAPFK DKGEGSMLRL EDLGDQRYAP
     YKYMLRLCYR VLRHSQQDYR KNQEYIAKNF CVMQSQIGYD ILAEDTITAL LHNNRKLLEK
     HITAKEIETF VNLLRRNREP RFLDYLSDLC VSNTTAIPVT QELICKFMLS PGNADILIQT
     KLVSTQMDNP LECPVISDDI DEEEVWLYWI DSNKEPHGKA IRHLAQEAKE GTKADLEVLT
     YYRYQLNLFA RMCLDRQYLA INQISAQLSV DLILRCMSDE SLPYDLRASF CRLMLHMHVD
     RDPQESVVPV KYARLWTEIP TKITIHEYDS FTDSSRNEMK TKFALTMEFV EEYLKEVVNQ
     PFPFGDKEKN KLTFEVVHLA RNLIYFGFYS FSELLRLTRT LLAILDIVQV PISSYFERLS
     KFQDGGNNVM RTIHGVGEMM TQMVLSRGSV FPISTPDIQP SIHPSKQTST ADSEDVIVMD
     TKLKIIEILQ FILSVRLDYR ISYMLSIYKR EFGENTENVD CSTSSPPDTP GTASAIVPDI
     DEIAAQAETM FAGRKEKNAV QLDDEGGRTF LRVLIHLIMH DYPPLLSGAL HLLFKHFSQR
     AEVLQAFKQV QLLVSNQDVD NYKQIKADLD QLRLTVEKSE LWVEKSSNYE SGEVGDNQTK
     GGEEPMEESN ILSPIQDGTK KPQIDSIKSN NYNIVKEILI RLSKLCVQNK KCRNQQQRLL
     KNMGAHLVVL DLLQIPYEKS DEKMNEVMNL AHTFLQNFCR GNPQNQVLLH KNLNLFLTPG
     LLEAETMRHI FMNNYLLCNE ISERVVQHFV HCIETHGRHV EYLRFLQTIV KADGKYVKKC
     QDMVMTELIN GGEDVLIFYN DRASFPVLLQ MMCSERDRAD ESGPLAYHIT LVELLAACTE
     GKNVYTEIKC NSLLPLDDIV RVVTHDDCIP EVKIAYVNFV NHCYVDTEVE MKEIYASNHI
     WKLFENFLVD MARVCNTTTD RKHADTSLEK YVTEPVMSIV SGFFNSPFSD NSTSLQTHQP
     VFIQLLQSAF RIYNCTWPNP TQKASVESCI KTLAEVAKNR GIAIPVDLDS QVNTLFMKSH
     SNMVQRAAMG WRMSARSGPR FKEALGGPAW DYRNIIEKLQ DVVSSLEQQF TPMMQAEFSV
     LVDVLHSPEL LFPEGSDARI RCGAFMSKLI NHTKKLMEKE EKLCIKILQT LREMLDKKTN
     FAEEGNTLRK ILLHRYFKGE YGSGMNGPLS ASYSKTAQVG GGFSGQDADK SGVTMFDIQC
     LLDKEGASEL VIDVIVNTRN DRIFSEGILL GIALLEGGNT QTQYSTYQQL KEQKKSERFF
     KVLYDRMKAA QQEIRSTVTV NTIDLGSKKK EDDSDLTISV PKKRVKDSTL HLKEGMKGQL
     TEASSATSKA YSVYRREMDP EIDLMGSGAD AANAEEKSAE EAIMSPAIAI MQPILRFLQL
     LCENHNRELQ NFLRHQNNKT NYNLVCETLQ FLDCICGSTT GGLGLLGLYI NERNVALVNQ
     TLESLTEYCQ GPCHENQTCI ATHESNGIDI IIALILNDIN PLGKYCMDLV LQLKNNASKL
     LLAIMESRQD SENAERILFN MRPRELVDVM KNAYNQGLEC DHEEENGDDG ISPKDVGHNI
     YILAHQLACH NKTLQQMLKP GSDPDEGDEA LRFYAKHTAQ IEIVRHDRTM EKIVFPVPNI
     CEFLTRESKS RVFNTTERDE QGSKVNDFFQ QTEDLYNEMK WQKKIRNNPA LFWFSRHISL
     WGSISFNLAV FINLAVALFY PFGDDGDEGT LSPLFSVLLW IAVAFCTAML FFISKPVGIR
     PFLVSVILRS IYTIGLGPTL ILLGAANLCN KIVFLVSFVG NRGTFTRGYR AVIMDMAFLY
     HVAYVLVCML GLCVHEFFYS FLLFDLVYRE ETLLNVIKSV TRNGRSIILT AVLALILVYL
     FSIIGFLFLK DDFIMEVDRL KIRTPAAGIG EVPTTTLTSM MGACAKENCS TSIPALNPGE
     EEEDGIERTC DTLLMCIVTV LNQGLRNGGG VGDVLRKPSK DEPLFAARVV YDLLFYFIVI
     IIVLNLIFGV IIDTFADLRS EKQKKEEILK TTCFICGLER DKFDNKTVSF EEHIKAEHNM
     WHYLYFIVLV KVKDPTEYTG PESYVAQMIV EKNLDWFPRM RAMSLVSNEG DSEQNEIRNL
     QERLESTMSL VKQLSSQLAE LKEQMTEQRK NKQRLGFLGS NTPHVNHHMP PP
//
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