ID   U3JNM5_FICAL            Unreviewed;       606 AA.
AC   U3JNM5;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Arylsulfatase D {ECO:0000313|Ensembl:ENSFALP00000004379.1};
GN   Name=ARSD {ECO:0000313|Ensembl:ENSFALP00000004379.1};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae; Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000004379.1, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000004379.1, ECO:0000313|Proteomes:UP000016665}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23103876; DOI=10.1038/nature11584;
RA   Ellegren H., Smeds L., Burri R., Olason P.I., Backstrom N., Kawakami T.,
RA   Kunstner A., Makinen H., Nadachowska-Brzyska K., Qvarnstrom A., Uebbing S.,
RA   Wolf J.B.;
RT   "The genomic landscape of species divergence in Ficedula flycatchers.";
RL   Nature 491:756-760(2012).
RN   [2] {ECO:0000313|Ensembl:ENSFALP00000004379.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
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DR   RefSeq; XP_005037714.1; XM_005037657.1.
DR   RefSeq; XP_005037715.1; XM_005037658.1.
DR   AlphaFoldDB; U3JNM5; -.
DR   STRING; 59894.ENSFALP00000004379; -.
DR   Ensembl; ENSFALT00000004402.2; ENSFALP00000004379.1; ENSFALG00000004200.2.
DR   GeneID; 101818212; -.
DR   KEGG; fab:101818212; -.
DR   eggNOG; KOG3867; Eukaryota.
DR   GeneTree; ENSGT00940000161140; -.
DR   HOGENOM; CLU_006332_13_4_1; -.
DR   OMA; HWNCIMM; -.
DR   OrthoDB; 2913702at2759; -.
DR   Proteomes; UP000016665; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd16159; ES; 1.
DR   Gene3D; 3.30.1120.10; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR42693:SF16; ARYLSULFATASE H; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   Pfam; PF14707; Sulfatase_C; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..606
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004645611"
FT   TRANSMEM        194..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          35..435
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   606 AA;  67935 MW;  C40957132825F953 CRC64;
     MIWQLTSHRS ALVTPLIFGL LLQAPRTQPS TITQPNFVLL LADDLGIGDV GCYGNDTIRT
     PNIDGLAEEG VKLTQHIAAA PLCTPSRAAF LTGRYPLRSG MDAVNDYRVI FWNAGSGGLP
     PNETTFAKIL QHQGYTTGLI GKWHQGVNCE SRNDHCHHPL KHGFDYFYGM PFTLISDCEP
     TEPPEMDRAF RRKLWLSTQV IGLITLTAVL GRLTGLISVH WKTLTCLAGF SLLFFISWFS
     SYGFVRHWNC IMMRNHEITE QPMVTERTTS LILRESISFI ERNKHKPFLL FLSFLHSHTP
     LLTTEKFLGK SRHGLYGDNV EEMDWMVGQV LDAIDKEGLK DTTLVYFASD HGGWLERQEG
     ERQLGGWNGI YKGGKAMGGW EGGIRVPGIF RWPGVLPAGK VIDEPTSLMD IYPGKVIDEP
     TSLMDIYPTV VHLAGGTVPQ DRVLDGRDLL PLLRGAAARS EHEFLFHYCG AHLHAVRWHH
     KDTGAVWKAH YVTPIFSPPG AGACYDRGFC PCFGEGVTHH EPPLLFELSQ DPSEANPLSA
     DTEPLFDTVI RRIGRAIEEH RRTLTPVPEQ LSVSNVVWKP WLQPCCGTFP FCWCDKEDDN
     NKLVDL
//